TFAP2A and DEK

Number of citations of the paper that reports this interaction (PMID 12595566)
25

Data Source:
HPRD (in vivo, in vitro)

		TFAP2A	DEK
Gene Name		transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	DEK proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Intracellular Membrane-bounded Organelle	Nucleus Contractile Fiber
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Transcription Coactivator Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity	DNA Binding Histone Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Outflow Tract Morphogenesis Keratinocyte Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Transcription From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Embryonic Body Morphogenesis Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Neural Crest Cell Development Anterior Neuropore Closure Trigeminal Nerve Development Oculomotor Nerve Formation Forebrain Neuron Development Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Embryonic Cranial Skeleton Morphogenesis Epidermis Morphogenesis Palate Development Lens Induction In Camera-type Eye Face Morphogenesis Bone Morphogenesis Eyelid Development In Camera-type Eye Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Basement Membrane Organization Metanephric Nephron Development Negative Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Chromatin Modification Viral Genome Replication Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CTNNB1 DEK EP300 EPN2 EPS15 GSTO2 HIP1 LDLRAP1 MAGI1 MKRN3 MYC NPM1 PPARG RB1 SP1 SRA1 SUMO4 SYT1 TP53 UBE2I WWP1 WWP2 YBX1	10 interactors: AP2A1 CREBBP CSNK2A1 EP300 HIST3H3 HLA-A KAT2B SRRM1 TFAP2A ZIK1
Entrez ID		7020	7913
HPRD ID		00128	00503
Ensembl ID		ENSG00000137203	ENSG00000124795
Uniprot IDs		P05549	B4DFG0 P35659
PDB IDs			1Q1V 2JX3
Enriched GO Terms of Interacting Partners?		Cell Death Death Apoptotic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Glial Cell Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Peptidase Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Cell Proliferation Regulation Of Cell Cycle Neuron Death Positive Regulation Of Gene Expression Regulation Of Cell Death Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Immune System Development Positive Regulation Of Proteolysis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated	N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Modification Viral Process Rhythmic Process Transcription, DNA-templated RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Defense Response To Virus By Virus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Nitrogen Compound Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Transcription From RNA Polymerase II Promoter Cellular Response To Heat Positive Regulation Of Cytokine Production Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Histone H2B Acetylation Optic Cup Structural Organization Positive Regulation Of Type I Interferon Production Histone Modification Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Oculomotor Nerve Formation Positive Regulation Of Memory T Cell Activation Optic Vesicle Morphogenesis
Tagcloud ?		blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs	abnormality basophils biomolecular chimaeric chromosomal cml continuously doubled eosinophils fkh granulocyte heterogenous leukaemia leukaemogenesis morphologies multilineage myelocytic myeloid myelomonocytic oft p23 permanent ph1 philadelphia pluripotent proliferating q34 rarely transcript
Tagcloud (Difference) ?		blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs	abnormality basophils biomolecular chimaeric chromosomal cml continuously doubled eosinophils fkh granulocyte heterogenous leukaemia leukaemogenesis morphologies multilineage myelocytic myeloid myelomonocytic oft p23 permanent ph1 philadelphia pluripotent proliferating q34 rarely transcript
Tagcloud (Intersection) ?