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TFAP2A and CASP1
Number of citations of the paper that reports this interaction (PubMedID
11438643
)
77
Data Source:
HPRD
(in vitro, in vivo)
TFAP2A
CASP1
Description
transcription factor AP-2 alpha
caspase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Membrane
Protein-containing Complex
Canonical Inflammasome Complex
IPAF Inflammasome Complex
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Protease Inhibitor Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Hydrolase Activity
Enzyme Binding
Kinase Binding
Cytokine Binding
Identical Protein Binding
CARD Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Kidney Development
Optic Vesicle Morphogenesis
Optic Cup Structural Organization
Regulation Of DNA-templated Transcription
Nervous System Development
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Retina Layer Formation
Negative Regulation Of Transcription By Competitive Promoter Binding
Trigeminal Nerve Development
Oculomotor Nerve Formation
Positive Regulation Of Bone Mineralization
Embryonic Forelimb Morphogenesis
Regulation Of Cell Population Proliferation
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Cranial Skeleton Morphogenesis
Roof Of Mouth Development
Bone Morphogenesis
Eyelid Development In Camera-type Eye
Positive Regulation Of Tooth Mineralization
Cellular Response To Iron Ion
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Plasma Membrane Repair
Pattern Recognition Receptor Signaling Pathway
Proteolysis
Apoptotic Process
Inflammatory Response
Signal Transduction
Osmosensory Signaling Pathway
Protein Secretion
Protein Autoprocessing
Protein Catabolic Process
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-18 Production
Interleukin-18-mediated Signaling Pathway
Defense Response To Bacterium
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Icosanoid Biosynthetic Process
Ceramide Biosynthetic Process
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Protein Maturation
Defense Response To Virus
Protein Poly-ADP-ribosylation
Pyroptotic Inflammatory Response
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Type II Interferon
Cytokine Precursor Processing
Signaling Receptor Ligand Precursor Processing
AIM2 Inflammasome Complex Assembly
Pyroptotic Cell Death
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
TFAP2 (AP-2) family regulates transcription of other transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
TFAP2 (AP-2) family regulates transcription of cell cycle factors
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Positive Regulation of CDH1 Gene Transcription
Regulation of MITF-M-dependent genes involved in pigmentation
Specification of the neural plate border
Specification of the neural plate border
Developmental Lineage of Mammary Stem Cells
NOD1/2 Signaling Pathway
Interleukin-1 processing
Pyroptosis
TP53 Regulates Transcription of Caspase Activators and Caspases
The NLRP3 inflammasome
The AIM2 inflammasome
The IPAF inflammasome
Interleukin-37 signaling
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Drugs
Acetylsalicylic acid
Minocycline
Pralnacasan
LAX-101
Emricasan
VX-765
1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
Z-Val-Ala-Asp fluoromethyl ketone
3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
Branchiooculofacial syndrome (BOFS)
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Breast cancer in BRCA2 mutation carriers (
23544012
)
Glucose homeostasis traits (
25524916
)
Iron status biomarkers (ferritin levels) (
28334935
)
Metabolite levels (
23823483
)
Ovarian cancer (
30557369
)
Refractive error (
32231278
)
Response to (pegylated) interferon in HBeAg-negative hepatitis B (
30715261
)
Zinc levels (
26025379
)
Hip circumference adjusted for BMI (
28552196
)
Interacting Genes
40 interacting genes:
APC
CASP1
CASP3
CASP6
CITED2
CITED4
CLTC
CSNK2A1
CSNK2B
CTNNB1
DEK
EP300
EPN1
EPN2
EPS15
GSTO2
HIP1
INCA1
KCTD15
LDLRAP1
MAGI1
MARK1
MKRN3
MYC
NFKB1
NPM1
OCRL
PPARG
PRKAA2
PRKD1
RB1
SRA1
SUMO4
SYT1
TP53
UBE2I
VEGFA
WWP1
WWP2
YBX1
46 interacting genes:
AR
ATN1
ATXN3
BCAP31
BCL2L1
BID
CARD16
CARD17P
CARD8
CASP10
CASP14
CASP8
CAST
CDK11B
CFTR
EGFR
FGF2
GSDMD
HTT
HUWE1
IL18
IL1A
IL1B
IL33
IL37
LMNA
MAPT
NEDD4
NFE2L2
NLRC4
NLRP1
NOD1
PAK1
PARP1
PLA2G4A
PLA2G4B
PRKN
PSEN1
PSEN2
PYCARD
RIPK2
RNF31
SERPINB9
TFAP2A
TIRAP
VAC14
Entrez ID
7020
834
HPRD ID
00128
00977
Ensembl ID
ENSG00000137203
ENSG00000137752
Uniprot IDs
A0A6E1XE14
P05549
A8K249
A8K257
P29466
PDB IDs
8J0K
8J0L
8J0R
1BMQ
1IBC
1ICE
1RWK
1RWM
1RWN
1RWO
1RWP
1RWV
1RWW
1RWX
1SC1
1SC3
1SC4
2FQQ
2H48
2H4W
2H4Y
2H51
2H54
2HBQ
2HBR
2HBY
2HBZ
3D6F
3D6H
3D6M
3E4C
3NS7
5FNA
5MMV
5MTK
6BZ9
6F6R
6KN0
6PZP
6VIE
7KEU
8SV1
8WRA
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Cytoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Signaling
Negative Regulation Of RNA Metabolic Process
Regulation Of Apoptotic Process
Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Cell Death
Negative Regulation Of DNA-templated Transcription
Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Clathrin Binding
Cell Surface Receptor Signaling Pathway
Identical Protein Binding
Positive Regulation Of Cell Communication
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nucleus
Regulation Of Signaling
Regulation Of Metabolic Process
Transcription Coregulator Binding
Regulation Of Protein Localization
Regulation Of Signal Transduction
Signal Transduction
Cytosol
Myeloid Cell Differentiation
Chromatin Binding
Glial Cell Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Wnt Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Communication
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription By RNA Polymerase II
Disordered Domain Specific Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Apoptotic Signaling Pathway
Negative Regulation Of Protein Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Programmed Cell Death
Cell Death
Response To Stress
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Cell Communication
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
Regulation Of Interleukin-1 Beta Production
Regulation Of Multicellular Organismal Process
Regulation Of Defense Response
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Inflammatory Response
Regulation Of Interleukin-1 Production
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Apoptotic Signaling Pathway
Regulation Of Cell Communication
Regulation Of Cytokine Production
Regulation Of Immune Response
Positive Regulation Of Cytokine Production
Response To External Biotic Stimulus
Positive Regulation Of Interleukin-1 Beta Production
Apoptotic Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Programmed Cell Death
Defense Response
Positive Regulation Of Defense Response
Positive Regulation Of Interleukin-1 Production
Defense Response To Bacterium
Identical Protein Binding
Negative Regulation Of Apoptotic Signaling Pathway
Cytosol
Protein-containing Complex
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Regulation Of Innate Immune Response
Response To Lipid
Regulation Of Immune System Process
Canonical Inflammasome Complex
Intracellular Signal Transduction
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