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TFAP2A and CLTC
Number of citations of the paper that reports this interaction (PubMedID
1587861
)
0
Data Source:
HPRD
(in vitro)
TFAP2A
CLTC
Description
transcription factor AP-2 alpha
clathrin heavy chain
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Endosome
Trans-Golgi Network
Spindle
Cytosol
Cytoskeleton
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Clathrin Coat
Clathrin Coat Of Trans-Golgi Network Vesicle
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Trans-Golgi Network Membrane
Protein-containing Complex
Centriolar Satellite
Endolysosome Membrane
Melanosome
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Clathrin Complex
Mitotic Spindle
Extracellular Vesicle
Mitotic Spindle Microtubule
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
RNA Binding
Double-stranded RNA Binding
Structural Molecule Activity
Protein Binding
Protein Kinase Binding
Clathrin Light Chain Binding
Low-density Lipoprotein Particle Receptor Binding
Disordered Domain Specific Binding
Ubiquitin-specific Protease Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Kidney Development
Optic Vesicle Morphogenesis
Optic Cup Structural Organization
Regulation Of DNA-templated Transcription
Nervous System Development
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Retina Layer Formation
Negative Regulation Of Transcription By Competitive Promoter Binding
Trigeminal Nerve Development
Oculomotor Nerve Formation
Positive Regulation Of Bone Mineralization
Embryonic Forelimb Morphogenesis
Regulation Of Cell Population Proliferation
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Cranial Skeleton Morphogenesis
Roof Of Mouth Development
Bone Morphogenesis
Eyelid Development In Camera-type Eye
Positive Regulation Of Tooth Mineralization
Cellular Response To Iron Ion
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Mitotic Cell Cycle
Osteoblast Differentiation
Intracellular Protein Transport
Receptor-mediated Endocytosis
Autophagy
Vesicle-mediated Transport
Receptor Internalization
Transferrin Transport
Retrograde Transport, Endosome To Golgi
Clathrin Coat Assembly
Cell Division
Regulation Of Mitotic Spindle Organization
Clathrin Coat Disassembly
Clathrin-dependent Endocytosis
Amyloid-beta Clearance By Transcytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
TFAP2 (AP-2) family regulates transcription of other transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
TFAP2 (AP-2) family regulates transcription of cell cycle factors
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Positive Regulation of CDH1 Gene Transcription
Regulation of MITF-M-dependent genes involved in pigmentation
Specification of the neural plate border
Specification of the neural plate border
Developmental Lineage of Mammary Stem Cells
Entry of Influenza Virion into Host Cell via Endocytosis
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
RHOU GTPase cycle
RHOV GTPase cycle
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Drugs
Diseases
Branchiooculofacial syndrome (BOFS)
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Breast cancer in BRCA2 mutation carriers (
23544012
)
Glucose homeostasis traits (
25524916
)
Iron status biomarkers (ferritin levels) (
28334935
)
Metabolite levels (
23823483
)
Ovarian cancer (
30557369
)
Refractive error (
32231278
)
Response to (pegylated) interferon in HBeAg-negative hepatitis B (
30715261
)
Zinc levels (
26025379
)
Interacting Genes
40 interacting genes:
APC
CASP1
CASP3
CASP6
CITED2
CITED4
CLTC
CSNK2A1
CSNK2B
CTNNB1
DEK
EP300
EPN1
EPN2
EPS15
GSTO2
HIP1
INCA1
KCTD15
LDLRAP1
MAGI1
MARK1
MKRN3
MYC
NFKB1
NPM1
OCRL
PPARG
PRKAA2
PRKD1
RB1
SRA1
SUMO4
SYT1
TP53
UBE2I
VEGFA
WWP1
WWP2
YBX1
70 interacting genes:
ACO1
AFTPH
AMPH
ANXA1
AP1B1
AP1G1
AP3B1
AP3B2
ARF6
ARMCX3
ARR3
ARRB1
ARRB2
BTG3
C10orf88
CEBPA
CLINT1
CLTA
CLTB
DNAJC6
DSCAM
DSCR9
DUX4
EPN1
EPN2
ERG
FYN
GAK
GGA1
GGA2
GGA3
GRIN1
GRIN2D
HGS
HIP1
HIP1R
ITSN1
KIT
LDLRAP1
MAP3K10
MAU2
NCALD
NDRG1
OCRL
OPTN
PICALM
PPP1CC
PRKACA
PXN
QARS1
RIPK4
SCYL2
SMAP1
SNX5
SNX9
SPATC1L
SRC
STAMBP
SUMO2
SYNJ1
TFAP2A
TNK2
TOM1
USP7
VCL
WNK1
XRCC6
YWHAG
YWHAQ
ZFYVE9
Entrez ID
7020
1213
HPRD ID
00128
00350
Ensembl ID
ENSG00000137203
ENSG00000141367
Uniprot IDs
A0A6E1XE14
P05549
A0A087WVQ6
Q00610
PDB IDs
8J0K
8J0L
8J0R
2XZG
4G55
6E4L
6QNN
6QNP
7BN1
7BN2
7ZX4
9C0Y
9C0Z
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Cytoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Signaling
Negative Regulation Of RNA Metabolic Process
Regulation Of Apoptotic Process
Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Cell Death
Negative Regulation Of DNA-templated Transcription
Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Clathrin Binding
Cell Surface Receptor Signaling Pathway
Identical Protein Binding
Positive Regulation Of Cell Communication
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nucleus
Regulation Of Signaling
Regulation Of Metabolic Process
Transcription Coregulator Binding
Regulation Of Protein Localization
Regulation Of Signal Transduction
Signal Transduction
Cytosol
Myeloid Cell Differentiation
Chromatin Binding
Glial Cell Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Wnt Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Communication
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Transcription By RNA Polymerase II
Disordered Domain Specific Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Apoptotic Signaling Pathway
Negative Regulation Of Protein Metabolic Process
Endocytosis
Clathrin Binding
Vesicle-mediated Transport
Import Into Cell
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Clathrin-coated Pit
Receptor-mediated Endocytosis
Early Endosome
Synaptic Vesicle Endocytosis
Regulation Of Vesicle-mediated Transport
Cytosol
Presynaptic Endocytosis
Endosome
Establishment Of Localization In Cell
Intracellular Transport
Regulation Of Endocytosis
Clathrin-dependent Endocytosis
Regulation Of Receptor-mediated Endocytosis
Cellular Localization
Establishment Of Protein Localization
Clathrin Vesicle Coat
Clathrin Coat Assembly
Clathrin Heavy Chain Binding
Phosphatidylinositol Binding
Protein Transport
Protein Localization To Cell Surface
Intracellular Protein Localization
Cytoplasm
Vesicle-mediated Transport In Synapse
Clathrin-coated Vesicle Membrane
Regulation Of Transport
Clathrin Coat Of Coated Pit
Early Endosome Membrane
Receptor Internalization
Intracellular Protein Transport
Golgi Apparatus
Cytoplasmic Vesicle Membrane
Presynapse
Phospholipid Binding
Regulation Of Clathrin Coat Assembly
Synaptic Vesicle Uncoating
Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Endosomal Transport
Membrane Coat
Perinuclear Region Of Cytoplasm
Protein Domain Specific Binding
Positive Regulation Of Cellular Component Organization
Clathrin Coat Disassembly
Clathrin Adaptor Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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