GPR25 and RHCG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR25	RHCG
Description		G protein-coupled receptor 25	Rh family C glycoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Protein Binding Ammonium Channel Activity Ankyrin Binding Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Intracellular Monoatomic Ion Homeostasis Regulation Of PH Amine Transport Epithelial Cell Differentiation Carbon Dioxide Transmembrane Transport Homeostatic Process Transepithelial Ammonium Transport Ammonium Transmembrane Transport Ammonium Homeostasis
Pathways		G alpha (s) signalling events	Rhesus glycoproteins mediate ammonium transport
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Refractive error ( 32231278)	Body size at age 10 ( 32376654) Dentures ( 31235808) Femur bone mineral density x serum urate levels interaction ( 34046847) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)
Interacting Genes		32 interacting genes: AQP6 ATP6V0C ATP6V0E1 BEST2 CNIH4 CREB3L1 CREB3L3 FATE1 GGT7 GJB1 IKBIP KASH5 LDLRAD1 LMNA MAP3K7 MMGT1 NAALADL2 PNMA1 RETN RHCG SHISAL1 SLC16A7 SLC35E3 SLC61A1 SLCO4A1 STOM TMEM237 TMEM248 TMEM52B TPRA1 TSPAN12 VAPB	13 interacting genes: ARLN C1QL4 CXCL9 ERMP1 FXYD6 GPR25 IGFBP5 MS4A13 TMEM60 TMEM97 TRARG1 UPK1B YIPF6
Entrez ID		2848	51458
HPRD ID		03707	16102
Ensembl ID		ENSG00000170128	ENSG00000140519
Uniprot IDs		O00155	Q9UBD6
PDB IDs			3HD6
Enriched GO Terms of Interacting Partners?		Membrane Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Proton-transporting V-type ATPase, V0 Domain Host-mediated Activation Of Viral Genome Replication Endoplasmic Reticulum Membrane Host-mediated Perturbation Of Viral Genome Replication Carbon Dioxide Transport Protein Binding Proton-transporting V-type ATPase Complex Response To Unfolded Protein Intracellular Monoatomic Ion Homeostasis Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of PH One-carbon Compound Transport Basolateral Plasma Membrane Monoatomic Ion Transport
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