GPR25 and TSPAN12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR25	TSPAN12
Description		G protein-coupled receptor 25	tetraspanin 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Protein Binding Wnt Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Angiogenesis Cell Surface Receptor Signaling Pathway Retina Layer Formation Maintenance Of Blood-brain Barrier Regulation Of Angiogenesis Norrin Signaling Pathway
Pathways		G alpha (s) signalling events
Drugs
Diseases			Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudative vitreoretinopathy2, X-linked (EVR2); Exudative vitreoretinopathy 4 (EVR4); Exudative vitreoretinopathy 5 (EVR5); Norrie disease (ND)
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Refractive error ( 32231278)	Bitter alcoholic beverage consumption ( 31046077) Heel bone mineral density ( 30598549)
Interacting Genes		32 interacting genes: AQP6 ATP6V0C ATP6V0E1 BEST2 CNIH4 CREB3L1 CREB3L3 FATE1 GGT7 GJB1 IKBIP KASH5 LDLRAD1 LMNA MAP3K7 MMGT1 NAALADL2 PNMA1 RETN RHCG SHISAL1 SLC16A7 SLC35E3 SLC61A1 SLCO4A1 STOM TMEM237 TMEM248 TMEM52B TPRA1 TSPAN12 VAPB	21 interacting genes: CDS2 CTXN3 CXCL16 CYBC1 EMP3 GPR25 GPR37L1 IGFBP5 MARCHF2 MGST3 NINJ2 PMP22 RFT1 RNF152 STX8 TEX264 TFCP2 TMEM140 TMEM147 TMEM182 TMEM218
Entrez ID		2848	23554
HPRD ID		03707	15509
Ensembl ID		ENSG00000170128	ENSG00000106025
Uniprot IDs		O00155	O95859
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Proton-transporting V-type ATPase, V0 Domain Host-mediated Activation Of Viral Genome Replication Endoplasmic Reticulum Membrane Host-mediated Perturbation Of Viral Genome Replication Carbon Dioxide Transport Protein Binding Proton-transporting V-type ATPase Complex Response To Unfolded Protein Intracellular Monoatomic Ion Homeostasis Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of PH One-carbon Compound Transport Basolateral Plasma Membrane Monoatomic Ion Transport	Membrane Bleb Assembly Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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