GPR25 and CREB3L3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR25	CREB3L3
Description		G protein-coupled receptor 25	cAMP responsive element binding protein 3 like 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Golgi Membrane Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription By RNA Polymerase II
Pathways		G alpha (s) signalling events	CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Refractive error ( 32231278)	Apolipoprotein A1 levels ( 32203549) Triglyceride levels ( 32203549)
Interacting Genes		32 interacting genes: AQP6 ATP6V0C ATP6V0E1 BEST2 CNIH4 CREB3L1 CREB3L3 FATE1 GGT7 GJB1 IKBIP KASH5 LDLRAD1 LMNA MAP3K7 MMGT1 NAALADL2 PNMA1 RETN RHCG SHISAL1 SLC16A7 SLC35E3 SLC61A1 SLCO4A1 STOM TMEM237 TMEM248 TMEM52B TPRA1 TSPAN12 VAPB	30 interacting genes: ATF6 BAD CEBPG CEP19 CREB3 CREB3L1 CSNK2A1 CYB561A3 DPY30 FATE1 GPR25 GSK3B KHDRBS1 KPNA2 MCRS1 MS4A13 PELI2 RHAG RIOK3 RUSF1 SGTA SGTB SLC38A7 SLC39A9 STX5 TCEANC TMEM239 TRAF3IP3 USP7 YIPF6
Entrez ID		2848	84699
HPRD ID		03707	16752
Ensembl ID		ENSG00000170128	ENSG00000060566
Uniprot IDs		O00155	Q68CJ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport Ammonium Transmembrane Transport Ammonium Channel Activity Proton-transporting V-type ATPase, V0 Domain Host-mediated Activation Of Viral Genome Replication Endoplasmic Reticulum Membrane Host-mediated Perturbation Of Viral Genome Replication Carbon Dioxide Transport Protein Binding Proton-transporting V-type ATPase Complex Response To Unfolded Protein Intracellular Monoatomic Ion Homeostasis Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of PH One-carbon Compound Transport Basolateral Plasma Membrane Monoatomic Ion Transport	Regulation Of Cellular Response To Stress Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process TRC Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Unfolded Protein Positive Regulation Of Type I Interferon Production Regulation Of Apoptotic Signaling Pathway Identical Protein Binding Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Poly(U) RNA Binding Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Golgi Membrane Membrane Protein Targeting To ER Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Macromolecule Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of DNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ER-nucleus Signaling Pathway Regulation Of Microtubule Anchoring At Centrosome Regulation Of Type I Interferon Production Golgi Apparatus Methylammonium Transmembrane Transporter Activity
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