NUF2 and ATF3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		NUF2	ATF3
Gene Name		NUF2, NDC80 kinetochore complex component	activating transcription factor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Cytosol Membrane Ndc80 Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Molecular_function Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Skeletal Muscle Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 SDCBP2	41 interactors: ATF2 ATF4 BATF BATF3 CEBPA CEBPE CEBPG CREB3 CREBBP DBP DDIT3 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUNB JUND LRIF1 MAFF MAFG MDM2 NFKB1 NUF2 PDX1 POLR3D SMAD3 SRA1 SS18L1 STAT1 SUMO1 SUMO3 SUV39H1 TP53 ZNF212
Entrez ID		83540	467
HPRD ID		10817	04395
Ensembl ID		ENSG00000143228	ENSG00000162772
Uniprot IDs		Q9BZD4	P18847
PDB IDs		2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Organization Spindle Stabilization Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Anchoring Mitotic Nuclear Division Mitotic Cell Cycle Microtubule-based Process Cellular Localization Histone-serine Phosphorylation Spindle Organization Organelle Localization Cell Division Microtubule Cytoskeleton Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Organelle Assembly Chromosome Organization Kinetochore Assembly Maintenance Of Location In Cell Protein Localization Cytoskeleton Organization Organelle Organization Kinetochore Organization Histone Phosphorylation Negative Regulation Of Microtubule Depolymerization Chromosome Segregation Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Division Centromere Complex Assembly Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cytokinesis Negative Regulation Of Protein Binding Establishment Of Organelle Localization Cellular Protein Complex Assembly Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Mitotic Sister Chromatid Segregation Spindle Assembly Protein Complex Assembly Sister Chromatid Segregation Cell Cycle Process Negative Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Cell Cycle Process Regulation Of Protein Depolymerization	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Cellular Metabolic Process Response To Organic Substance Regulation Of Cell Differentiation Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Defense Response Cellular Response To Organic Substance Cell Differentiation Immune System Process Histone H3-K9 Modification Developmental Process Rhythmic Process Regulation Of Cell Death Response To Biotic Stimulus
Tagcloud ?		ams2 ams2p bioinformatics cenpa centromere centromeres centromeric cnp1 cnp1p defining disrupted gata identifies incorporation kinetochore linker mal2 microarrays mis12 mis18 nucleosome nucleosomes participating pombe positioned positioning regularly schizosaccharomyces tiling	activating attenuation beneficial caat chop combating contributes diabetogenic dietary elevation elicited endoplasmic enhancer evoked fatty hdac1 hdac3 homologous islets lipotoxicity mimicked min6 ms palmitate preserving prevents reticulum saturated silencing
Tagcloud (Difference) ?		ams2 ams2p bioinformatics cenpa centromere centromeres centromeric cnp1 cnp1p defining disrupted gata identifies incorporation kinetochore linker mal2 microarrays mis12 mis18 nucleosome nucleosomes participating pombe positioned positioning regularly schizosaccharomyces tiling	activating attenuation beneficial caat chop combating contributes diabetogenic dietary elevation elicited endoplasmic enhancer evoked fatty hdac1 hdac3 homologous islets lipotoxicity mimicked min6 ms palmitate preserving prevents reticulum saturated silencing
Tagcloud (Intersection) ?