NUF2 and NDC80

Number of citations of the paper that reports this interaction (PubMedID 31839598)
57

Data Source:
BioGRID (cross-linking study)
HPRD (two hybrid)

		NUF2	NDC80
Description		NUF2 component of NDC80 kinetochore complex	NDC80 kinetochore complex component
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane Ndc80 Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Membrane Nuclear Speck Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding Protein-containing Complex Binding	Protein Binding Microtubule Binding Cyclin Binding Identical Protein Binding Kinetochore Adaptor Activity
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Meiotic Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling G2/MI Transition Of Meiotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Chromosome Organization Centrosome Duplication Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nuclear Chromosome Segregation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 29273806) Bipolar disorder ( 34002096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Diffusing capacity of carbon monoxide ( 30694715) Height ( 28552196) Myopia ( 27182965)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		11 interacting genes: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 OGT SDCBP2	57 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CEP63 CIP2A CKAP5 EXOC8 GOLGA2 HAUS1 HGS IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 SFR1 SKA1 SKA3 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT
Entrez ID		83540	10403
HPRD ID		10817	06277
Ensembl ID		ENSG00000143228	ENSG00000080986
Uniprot IDs		Q9BZD4	A8K031 O14777
PDB IDs		2VE7 3IZ0 8G0P	2IGP 2VE7 3IZ0 8G0P
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Organization Membraneless Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Kinetochore Kinetochore Organization Organelle Assembly Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Midzone Attachment Of Spindle Microtubules To Kinetochore Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis I Chromosome, Centromeric Region Kinetochore Binding Chromosome Passenger Complex Midbody Cell Cycle G2/M Phase Transition Microtubule Cytoskeleton Organization Microtubule-based Process Mitotic Spindle Midzone Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Spindle Assembly Involved In Female Meiosis Kinetochore Assembly Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly Regulation Of Sister Chromatid Segregation Condensed Chromosome, Centromeric Region Positive Regulation Of Cell Cycle Checkpoint Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Meiotic Spindle Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Segregation Regulation Of Nuclear Division Protein Serine/threonine/tyrosine Kinase Activity Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Division Organelle Localization Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Spindle Microtubule Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle	Kinetochore Cell Division Chromosome, Centromeric Region Organelle Organization Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Centrosome Regulation Of Chromosome Separation Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Microtubule-based Process Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Mitotic Sister Chromatid Segregation Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Sister Chromatid Segregation Regulation Of Sister Chromatid Segregation Spindle Pole Cytoskeleton Organization Regulation Of Chromosome Segregation Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Spindle Regulation Of Chromosome Organization Positive Regulation Of Mitotic Sister Chromatid Separation Organelle Assembly Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Process Microtubule Chromosome Organization Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cell Cycle
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