NUF2 and AZGP1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NUF2	AZGP1
Name		NUF2 component of NDC80 kinetochore complex	alpha-2-glycoprotein 1, zinc-binding
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane Ndc80 Complex	Extracellular Region Extracellular Space Nucleus External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Protein-containing Complex Binding	RNA Nuclease Activity Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Meiotic Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Cell Adhesion Negative Regulation Of Cell Population Proliferation Protein Transmembrane Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Miscellaneous transport and binding events
Drugs		None	N-acetyl-alpha-neuraminic acid Copper
GWAS		Asthma ( 29273806 ) Bipolar disorder ( 34002096 ) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168 ) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683 ) Diffusing capacity of carbon monoxide ( 30694715 ) Height ( 28552196 ) Myopia ( 27182965 )	Brain morphology (MOSTest) ( 32665545 ) Red blood cell count ( 27863252 ) Refractive error ( 32231278 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		2 novel interactors: ADCY2 FCRLA	None recorded
Interacting Genes		11 interacting genes: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 OGT SDCBP2	5 interacting genes: ABCC1 ITGAV NUF2 SHBG UBQLN2
Entrez ID		83540	563
HPRD ID		10817	01910
Ensembl ID		ENSG00000143228	ENSG00000160862
Uniprot IDs		Q9BZD4	A0A140VK00 P25311
PDB IDs		2VE7 3IZ0 8G0P	1T7V 1T7W 1T7X 1T7Y 1T7Z 1T80 1ZAG 3ES6 6R2U
GO Terms Enriched among Interactors		Mitotic Spindle Organization Membraneless Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Kinetochore Kinetochore Organization Organelle Assembly Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Midzone Attachment Of Spindle Microtubules To Kinetochore Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis I Chromosome, Centromeric Region Kinetochore Binding Chromosome Passenger Complex Midbody Cell Cycle G2/M Phase Transition Microtubule Cytoskeleton Organization Microtubule-based Process Mitotic Spindle Midzone Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Spindle Assembly Involved In Female Meiosis Kinetochore Assembly Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly Regulation Of Sister Chromatid Segregation Condensed Chromosome, Centromeric Region Positive Regulation Of Cell Cycle Checkpoint Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Meiotic Spindle Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Segregation Regulation Of Nuclear Division Protein Serine/threonine/tyrosine Kinase Activity Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Division Organelle Localization Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Spindle Microtubule Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle	Entry Into Host Cell By A Symbiont-containing Vacuole Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Opsonin Binding Integrin Alphav-beta8 Complex ABC-type Vitamin B12 Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Sphingolipid Transporter Activity Negative Regulation Of G Protein-coupled Receptor Internalization Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Alphav-beta3 Integrin-PKCalpha Complex Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Extracellular Matrix Protein Binding Sphingolipid Translocation Carboxylic Acid Transmembrane Transporter Activity Androgen Binding Negative Regulation Of Clathrin-dependent Endocytosis Ndc80 Complex Xenobiotic Transport Across Blood-brain Barrier Regulation Of Entry Of Bacterium Into Host Cell Transforming Growth Factor Beta Production Glutathione Transmembrane Transporter Activity Leukotriene Transport Locomotion Negative Regulation Of Low-density Lipoprotein Particle Clearance Insulin-like Growth Factor I Binding Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Osteoblast Proliferation Chemotaxis Regulation Of Endocytosis Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cyclic Nucleotide Transport Efflux Transmembrane Transporter Activity Porphyrin-containing Compound Catabolic Process ABC-type Xenobiotic Transporter Activity Glutathione Transport Glutathione Transmembrane Transport Cobalamin Transport ABC-type Glutathione S-conjugate Transporter Activity Heme Catabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Meiotic Chromosome Segregation Wound Healing, Spreading Of Epidermal Cells