ANKZF1 and STAT6

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ANKZF1	STAT6
Gene Name		ankyrin repeat and zinc finger domain containing 1	signal transducer and activator of transcription 6, interleukin-4 induced
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Nuclear Chromatin Nucleoplasm Cytoplasm Cytosol Membrane Raft
	Molecular Function	Protein Binding Metal Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Type I Interferon Production Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Reactive Nitrogen Species
Pathways			Signaling by PDGF Downstream signal transduction Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS			Eosinophilic esophagitis (pediatric) ( 20208534) IgE levels ( 22075330)
Protein-Protein Interactions		7 interactors: APP AURKB CA2 CTTN DNAJB11 NRSN2 STAT6	37 interactors: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 HIST2H3C IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		55139	6778
HPRD ID		07673	03302
Ensembl ID		ENSG00000163516	ENSG00000166888
Uniprot IDs		Q9H8Y5	A8K4S9 B4DQB3 P42226
PDB IDs			1OJ5
Enriched GO Terms of Interacting Partners?		T-helper 1 Cell Lineage Commitment Synaptic Growth At Neuromuscular Junction Positive Regulation Of Dipeptide Transmembrane Transport Regulation Of Protein Binding Histone H3-S28 Phosphorylation Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular PH Reduction Interleukin-4-mediated Signaling Pathway Spindle Stabilization Regulation Of Chloride Transport Positive Regulation Of Isotype Switching To IgE Isotypes Collateral Sprouting Axon Midline Choice Point Recognition Abscission Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cell Cycle Process Axon Choice Point Recognition Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation T-helper Cell Lineage Commitment Angiotensin-activated Signaling Pathway Dendritic Spine Maintenance Regulation Of Binding T-helper 1 Cell Differentiation Negative Regulation Of Cytokinesis CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Neuron Remodeling Protein Localization To Kinetochore Positive Regulation Of Cell Cycle Anatomical Structure Morphogenesis Response To Abiotic Stimulus Substrate-dependent Cell Migration, Cell Extension Spindle Midzone Assembly Regulation Of Developmental Growth Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Type 2 Immune Response Cell Adhesion Response To Light Stimulus Cellular Protein Complex Assembly Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Synaptic Transmission, GABAergic Multicellular Organismal Development Positive Regulation Of Bone Resorption Cellular Response To Reactive Nitrogen Species Histone-serine Phosphorylation Cellular Response To Fluid Shear Stress Positive Regulation Of Isotype Switching	Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Gene Expression Regulation Of Gene Expression RNA Metabolic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune Response Cellular Nitrogen Compound Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Hormone Response To Stress Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Immune System Process Positive Regulation Of Cytokine Production Response To Cytokine Regulation Of Cellular Process Response To Biotic Stimulus Cellular Response To Hormone Stimulus Cellular Metabolic Process Innate Immune Response Regulation Of Cell Differentiation
Tagcloud ?			13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Difference) ?			13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Intersection) ?