NSUN2 and CCR4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		NSUN2	CCR4
Description		NOP2/Sun RNA methyltransferase 2	C-C motif chemokine receptor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Cytoskeleton Chromatoid Body Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity TRNA (cytidine-5-)-methyltransferase Activity Transferase Activity MRNA (cytidine-5-)-methyltransferase Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	RNA Methylation In Utero Embryonic Development MRNA Processing TRNA Modification Spermatogenesis Spermatid Development TRNA Processing Regulation Of MRNA Export From Nucleus Cell Differentiation TRNA Methylation Methylation Meiotic Cell Cycle Checkpoint Signaling TRNA Stabilization Hair Follicle Maturation Cell Division Regulation Of Stem Cell Differentiation	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration
Pathways		tRNA modification in the nucleus and cytosol tRNA modification in the nucleus and cytosol	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Mogamulizumab FLX475
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Visceral fat ( 22589738)	Asthma ( 31959851) Celiac disease ( 20190752 22057235) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		7 interacting genes: AURKB CCR4 CDKN1A CEBPA NRIP1 RNF10 SUMO2	37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1
Entrez ID		54888	1233
HPRD ID		08620	05324
Ensembl ID		ENSG00000037474	ENSG00000183813
Uniprot IDs		Q08J23	A0N0Q1 P51679
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To UV Positive Regulation Of Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cellular Response To Light Stimulus Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Kinase Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process Regeneration CHOP-C/EBP Complex Histone Deacetylase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Radiation Cell Cycle Phase Transition Cellular Response To Cell-matrix Adhesion White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Mitotic Cytokinesis Checkpoint Signaling Positive Regulation Of Microtubule Depolymerization Sister Chromatid Biorientation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process	Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response
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