NSUN2 and AURKB

Number of citations of the paper that reports this interaction (PubMedID 17215513)
42

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		NSUN2	AURKB
Description		NOP2/Sun RNA methyltransferase 2	aurora kinase B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Cytoskeleton Chromatoid Body Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity TRNA (cytidine-5-)-methyltransferase Activity Transferase Activity MRNA (cytidine-5-)-methyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Protein Serine Kinase Activity
	Biological Process	RNA Methylation In Utero Embryonic Development MRNA Processing TRNA Modification Spermatogenesis Spermatid Development TRNA Processing Regulation Of MRNA Export From Nucleus Cell Differentiation TRNA Methylation Methylation Meiotic Cell Cycle Checkpoint Signaling TRNA Stabilization Hair Follicle Maturation Cell Division Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of B Cell Apoptotic Process Spindle Organization Mitotic Spindle Organization Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Telomere Maintenance Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Microtubule-based Process Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Post-translational Protein Modification Cell Cycle G2/M Phase Transition Mitotic Cytokinesis Checkpoint Signaling Negative Regulation Of Innate Immune Response Mitotic Spindle Midzone Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Midbody Abscission Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Repair Of Mitotic Kinetochore Microtubule Attachment Defect CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Biorientation
Pathways		tRNA modification in the nucleus and cytosol tRNA modification in the nucleus and cytosol	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation
Drugs			Hesperidin AT9283 Enzastaurin Reversine Fostamatinib TAK-901
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Visceral fat ( 22589738)	Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)
Interacting Genes		7 interacting genes: AURKB CCR4 CDKN1A CEBPA NRIP1 RNF10 SUMO2	57 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CDH1 CENPA CIB1 DCUN1D1 DES EVI5 FBXL2 FLOT1 GANAB GAS2L3 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LIN28B LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SHCBP1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I USP37
Entrez ID		54888	9212
HPRD ID		08620	05397
Ensembl ID		ENSG00000037474	ENSG00000178999
Uniprot IDs		Q08J23	Q96GD4
PDB IDs			4AF3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To UV Positive Regulation Of Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cellular Response To Light Stimulus Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Kinase Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process Regeneration CHOP-C/EBP Complex Histone Deacetylase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Radiation Cell Cycle Phase Transition Cellular Response To Cell-matrix Adhesion White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Mitotic Cytokinesis Checkpoint Signaling Positive Regulation Of Microtubule Depolymerization Sister Chromatid Biorientation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process	Cell Division Spindle Spindle Organization Cytoskeleton Microtubule Cytoskeleton Organization Spindle Assembly Cytoskeleton Organization Regulation Of Chromosome Separation Microtubule-based Process Regulation Of Cell Cycle Midbody Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Microtubule Binding Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Organelle Organization Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Nuclear Chromosome Segregation Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Positive Regulation Of Chromosome Separation Membraneless Organelle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Cellular Component Organization Chromosome, Centromeric Region Regulation Of Organelle Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Process Microtubule Cytoskeleton Regulation Of Protein-containing Complex Assembly Mitotic Spindle Midzone Assembly Regulation Of Cytokinesis Mitotic Cell Cycle Centrosome Cytoskeleton-dependent Cytokinesis Regulation Of Nuclear Division Mitotic Spindle Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Metaphase Chromosome Alignment Spindle Midzone Assembly Spindle Assembly Involved In Female Meiosis Mitotic Cytokinesis
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