NSUN2

Description		NOP2/Sun RNA methyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Cytoskeleton Chromatoid Body Extracellular Exosome
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity TRNA (cytidine-5-)-methyltransferase Activity Transferase Activity MRNA (cytidine-5-)-methyltransferase Activity
	Biological Process	RNA Methylation In Utero Embryonic Development MRNA Processing TRNA Modification Spermatogenesis Spermatid Development TRNA Processing Regulation Of MRNA Export From Nucleus Cell Differentiation TRNA Methylation Methylation Meiotic Cell Cycle Checkpoint Signaling TRNA Stabilization Hair Follicle Maturation Cell Division Regulation Of Stem Cell Differentiation
Pathways		tRNA modification in the nucleus and cytosol tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Visceral fat ( 22589738)
Interacting Genes		7 interacting genes: AURKB CCR4 CDKN1A CEBPA NRIP1 RNF10 SUMO2
Entrez ID		54888
HPRD ID		08620
Ensembl ID		ENSG00000037474
Uniprot IDs		Q08J23
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To UV Positive Regulation Of Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cellular Response To Light Stimulus Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Kinase Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process Regeneration CHOP-C/EBP Complex Histone Deacetylase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Radiation Cell Cycle Phase Transition Cellular Response To Cell-matrix Adhesion White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Mitotic Cytokinesis Checkpoint Signaling Positive Regulation Of Microtubule Depolymerization Sister Chromatid Biorientation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process
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