TGFBR3 and ARRB2

Number of citations of the paper that reports this interaction (PubMedID 12958365)
0

Data Source:
HPRD (in vivo)

		TGFBR3	ARRB2
Description		transforming growth factor beta receptor 3	arrestin beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome Cell Periphery	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Endocytic Vesicle Membrane Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding BMP Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding D1 Dopamine Receptor Binding Protein Kinase B Binding Molecular Adaptor Activity
	Biological Process	Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Positive Regulation Of Gene Expression Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Protein-containing Complex Assembly Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly	Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Adult Walking Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Sensory Perception Of Pain Negative Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Postsynaptic Signal Transduction Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Signaling by Activin Signaling by Activin FGFR1b ligand binding and activation FGFR1c ligand binding and activation Signaling by BMP TGF-beta receptor signaling activates SMADs TGFBR3 PTM regulation TGFBR3 regulates TGF-beta signaling TGFBR3 expression TGFBR3 regulates FGF2 signaling TGFBR3 regulates activin signaling	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants TGFBR3 regulates TGF-beta signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bone mineral density ( 19249006) Carotid plaque burden ( 28282560) dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung function (FEV1/FVC) ( 30804560 28166213) Lung function (FVC) ( 26635082 30804560) Metamizole-induced agranulocytosis or neutropenia ( 33138277) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 21307088 28073927 31798171) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Type 2 diabetes ( 23209189) Vertical cup-disc ratio ( 31798171 28073927 25241763) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Behcet's disease ( 33393726) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2	60 interacting genes: ADRB2 AGTR1 AGTR2 AP1B1 AP2M1 ARF6 AVPR2 BCAS1 C5AR1 CDC42 CLTC CRHR1 CSNK2A1 CSNK2A2 CXCR4 CYTH2 DLG4 DVL2 EGFR EIF2AK4 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MAS1 MDM2 MED8 NDUFS7 NEDD4L NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 SNCA STC2 SUMO1 SUMO2 TGFBR3 TRH UBC UBE2I
Entrez ID		7049	409
HPRD ID		02846	00147
Ensembl ID		ENSG00000069702	ENSG00000141480
Uniprot IDs		A0A0A8KWK3 Q03167	K7ENA6 P32121 Q59EM5 Q68DZ5
PDB IDs		7LBG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Type III Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Outflow Tract Septum Morphogenesis Gland Morphogenesis Odontogenesis Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Multicellular Organismal Process Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Animal Organ Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Developmental Process Activin Binding Response To Growth Factor Growth Factor Activity Negative Regulation Of Macrophage Cytokine Production Cell Surface Receptor Signaling Pathway Animal Organ Development Negative Regulation Of Cytokine Production Secondary Palate Development Anatomical Structure Morphogenesis Artery Morphogenesis Vasculogenesis Positive Regulation Of Cardiocyte Differentiation Transforming Growth Factor Beta Receptor Binding System Development Cardiac Septum Morphogenesis Response To Wounding Roof Of Mouth Development Cytokine Activity	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Plasma Membrane Signal Transduction Regulation Of Biological Quality Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase Activity Clathrin-coated Endocytic Vesicle Membrane Angiotensin Type II Receptor Activity Regulation Of Transport Positive Regulation Of Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Metal Ion Transport Regulation Of MAPK Cascade Regulation Of System Process Regulation Of Systemic Arterial Blood Pressure Glutamatergic Synapse Regulation Of Developmental Process Positive Regulation Of Locomotion Negative Regulation Of Systemic Arterial Blood Pressure Ubiquitin Protein Ligase Binding Enzyme Binding Blood Vessel Diameter Maintenance Regulation Of Tube Size Kinase Activity Import Into Cell Postsynapse Regulation Of Monoatomic Ion Transport Response To Stress Regulation Of Blood Pressure Neuron Spine Positive Regulation Of Neuron Projection Arborization Endocytosis Positive Regulation Of Cell Migration
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