TGFBR3 and ACVR2A

Number of citations: 0 (PubMedID 10746731)
Data Source: HPRD (in vivo)

		TGFBR3	ACVR2A
Name		transforming growth factor beta receptor 3	activin A receptor type 2A
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome Cell Periphery	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding BMP Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity
	Biological Process	Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Positive Regulation Of Gene Expression Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Protein-containing Complex Assembly Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus
Pathways		Signaling by Activin Signaling by Activin FGFR1b ligand binding and activation FGFR1c ligand binding and activation Signaling by BMP TGF-beta receptor signaling activates SMADs TGFBR3 PTM regulation TGFBR3 regulates TGF-beta signaling TGFBR3 expression TGFBR3 regulates FGF2 signaling TGFBR3 regulates activin signaling	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling
Drugs		None	Sotatercept
GWAS		Appendicular lean mass ( 33097823 ) Bone mineral density ( 19249006 ) Carotid plaque burden ( 28282560 ) dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292 ) Gestational age at birth (maternal effect) ( 28877031 ) Glaucoma (primary open-angle) ( 33627673 25861811 ) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Heel bone mineral density ( 30598549 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Lung function (FVC) ( 26635082 30804560 ) Metamizole-induced agranulocytosis or neutropenia ( 33138277 ) Multiple sclerosis ( 31604244 ) Optic disc area ( 25631615 21307088 28073927 31798171 ) Optic disc parameters ( 20548946 ) Optic disc size ( 31809533 ) Optic nerve measurement (cup-to-disc ratio) ( 28061514 ) Peak expiratory flow ( 30804560 ) Pulse pressure ( 30224653 ) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329 ) Type 2 diabetes ( 23209189 ) Vertical cup-disc ratio ( 31798171 28073927 25241763 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Arterial stiffness index ( 31235810 ) Asthma (adult onset) ( 31036433 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Cerebrospinal T-tau levels ( 28247064 ) Diastolic blood pressure ( 30224653 ) Eosinophil count ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Feeling nervous ( 29500382 ) Feeling tense ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Glomerular filtration rate (creatinine) ( 26831199 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol levels ( 32203549 ) High myopia ( 31816047 ) Loneliness (MTAG) ( 29970889 ) Neutrophil percentage of granulocytes ( 27863252 ) Photic sneeze reflex ( 30899065 ) Refractive error ( 32231278 ) Response to statin therapy ( 20339536 ) Retinal detachment or retinal break ( 31816047 ) Urate levels ( 31985003 23263486 ) White blood cell count (basophil) ( 27863252 )
Interacting Genes		13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2	23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3
Entrez ID		7049	92
HPRD ID		02846	00025
Ensembl ID		ENSG00000069702	ENSG00000121989
Uniprot IDs		A0A0A8KWK3 Q03167	P27037
PDB IDs		7LBG	3Q4T 3SOC 4ASX 5NH3 7U5P
GO Terms Enriched among Interactors		Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Type III Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Outflow Tract Septum Morphogenesis Gland Morphogenesis Odontogenesis Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Multicellular Organismal Process Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Animal Organ Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Developmental Process Activin Binding Response To Growth Factor Growth Factor Activity Negative Regulation Of Macrophage Cytokine Production Cell Surface Receptor Signaling Pathway Animal Organ Development Negative Regulation Of Cytokine Production Secondary Palate Development Anatomical Structure Morphogenesis Artery Morphogenesis Vasculogenesis Positive Regulation Of Cardiocyte Differentiation Transforming Growth Factor Beta Receptor Binding System Development Cardiac Septum Morphogenesis Response To Wounding Roof Of Mouth Development Cytokine Activity	Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation