TGFBR3 and ACVR2A

Number of citations of the paper that reports this interaction (PMID 10746731)
74

Data Source:
HPRD (in vivo)

		TGFBR3	ACVR2A
Gene Name		transforming growth factor, beta receptor III	activin A receptor, type IIA
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding
	Biological Process	Blood Vessel Development Response To Hypoxia Blastocyst Development Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Cell Growth Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Regulation Of Protein Binding Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Palate Development Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To BMP Stimulus
Pathways			Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS		Bone mineral density ( 19249006) Optic disc parameters ( 20548946 21307088) Type 2 diabetes ( 23209189)	Response to statin therapy ( 20339536) Urate levels ( 23263486)
Protein-Protein Interactions		13 interactors: ACVR2A ARRB2 ENG GIPC1 INHA INHBA NRP1 SDC2 TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR2	17 interactors: ACVRL1 BMP10 BMP6 BMP7 ENG ERBB2IP GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 SYNJ2BP TCTEX1D4 TGFBR3
Entrez ID		7049	92
HPRD ID		02846	00025
Ensembl ID		ENSG00000069702	ENSG00000121989
Uniprot IDs		Q03167	B4DWQ2 P27037
PDB IDs			3Q4T 3SOC 4ASX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Response To Wounding Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Cytokine Production Regulation Of Signal Transduction Ovulation Cycle Process Positive Regulation Of Ossification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovulation Cycle Regulation Of Signaling Skeletal System Development Positive Regulation Of Bone Mineralization Wound Healing Regulation Of Cell Differentiation Positive Regulation Of Biomineral Tissue Development Regulation Of MAPK Cascade Salivary Gland Morphogenesis SMAD Protein Import Into Nucleus Cell Growth Salivary Gland Development Negative Regulation Of Cell Proliferation Gland Morphogenesis Response To Organic Substance Negative Regulation Of Immune System Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Negative Regulation Of Signaling Single Organism Reproductive Process Exocrine System Development	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Signal Transduction Negative Regulation Of Cell Migration Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Motility Cell Differentiation Negative Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Component Movement Signaling Cell Communication Negative Regulation Of Locomotion Regulation Of Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Tissue Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Growth Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Stimulus Response To Growth Factor
Tagcloud ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically zfp423	5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423