TGFBR3 and TGFB3

Number of citations: 0 (PubMedID 11382746)
Data Source: HPRD (in vitro)

		TGFBR3	TGFB3
Name		transforming growth factor beta receptor 3	transforming growth factor beta 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome Cell Periphery	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding BMP Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transforming Growth Factor Beta Binding
	Biological Process	Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Positive Regulation Of Gene Expression Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Protein-containing Complex Assembly Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly	Response To Hypoxia In Utero Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Population Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Positive Regulation Of Protein Secretion Positive Regulation Of Cellular Component Organization Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly
Pathways		Signaling by Activin Signaling by Activin FGFR1b ligand binding and activation FGFR1c ligand binding and activation Signaling by BMP TGF-beta receptor signaling activates SMADs TGFBR3 PTM regulation TGFBR3 regulates TGF-beta signaling TGFBR3 expression TGFBR3 regulates FGF2 signaling TGFBR3 regulates activin signaling	Platelet degranulation Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs ECM proteoglycans
Drugs		None	1,4-Dioxane
Diseases		None	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Allograft rejection Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS		Appendicular lean mass ( 33097823 ) Bone mineral density ( 19249006 ) Carotid plaque burden ( 28282560 ) dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292 ) Gestational age at birth (maternal effect) ( 28877031 ) Glaucoma (primary open-angle) ( 33627673 25861811 ) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Heel bone mineral density ( 30598549 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Lung function (FVC) ( 26635082 30804560 ) Metamizole-induced agranulocytosis or neutropenia ( 33138277 ) Multiple sclerosis ( 31604244 ) Optic disc area ( 25631615 21307088 28073927 31798171 ) Optic disc parameters ( 20548946 ) Optic disc size ( 31809533 ) Optic nerve measurement (cup-to-disc ratio) ( 28061514 ) Peak expiratory flow ( 30804560 ) Pulse pressure ( 30224653 ) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329 ) Type 2 diabetes ( 23209189 ) Vertical cup-disc ratio ( 31798171 28073927 25241763 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	Height ( 33713608 )
Interacting Genes		13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2	13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		7049	7043
HPRD ID		02846	01829
Ensembl ID		ENSG00000069702	ENSG00000119699
Uniprot IDs		A0A0A8KWK3 Q03167	A5YM40 B3KVH9 P10600
PDB IDs		7LBG	1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9 8V52 8VS6 8VSB 9B9F 9FK5
GO Terms Enriched among Interactors		Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Type III Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Outflow Tract Septum Morphogenesis Gland Morphogenesis Odontogenesis Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Multicellular Organismal Process Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Animal Organ Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Developmental Process Activin Binding Response To Growth Factor Growth Factor Activity Negative Regulation Of Macrophage Cytokine Production Cell Surface Receptor Signaling Pathway Animal Organ Development Negative Regulation Of Cytokine Production Secondary Palate Development Anatomical Structure Morphogenesis Artery Morphogenesis Vasculogenesis Positive Regulation Of Cardiocyte Differentiation Transforming Growth Factor Beta Receptor Binding System Development Cardiac Septum Morphogenesis Response To Wounding Roof Of Mouth Development Cytokine Activity	Transforming Growth Factor Beta Binding Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Mesenchymal Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Artery Morphogenesis Endocardial Cushion Morphogenesis Heart Trabecula Morphogenesis Regulation Of Cartilage Development Cardiac Septum Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Morphogenesis Activin Receptor Activity, Type I Regulation Of Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Cell Migration Negative Regulation Of Epithelial Cell Proliferation Regulation Of Chondrocyte Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Activity Cardiac Muscle Tissue Morphogenesis Secondary Palate Development Regulation Of Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Ventricular Trabecula Myocardium Morphogenesis Cell Surface Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Muscle Tissue Morphogenesis Wound Healing Tissue Morphogenesis Response To Wounding Roof Of Mouth Development Tissue Development Glycosaminoglycan Binding