TGFBR3 and INHA

Number of citations: 0 (PubMedID 10746731)
Data Source: HPRD (in vivo)

		TGFBR3	INHA
Name		transforming growth factor beta receptor 3	inhibin subunit alpha
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Exosome Cell Periphery	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Extracellular Space Inhibin-betaglycan-ActRII Complex Neuronal Cell Body Inhibin A Complex Inhibin B Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding BMP Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Inhibin Binding Protein-containing Complex Binding
	Biological Process	Response To Hypoxia Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Positive Regulation Of Gene Expression Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Animal Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Epithelial Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Epicardium-derived Cardiac Fibroblast Cell Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Heart Trabecula Morphogenesis Secondary Palate Development Protein-containing Complex Assembly Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly	Skeletal System Development Ovarian Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Male Gonad Development Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Type II Interferon Production Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Hemoglobin Biosynthetic Process Negative Regulation Of B Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion System Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Cycle
Pathways		Signaling by Activin Signaling by Activin FGFR1b ligand binding and activation FGFR1c ligand binding and activation Signaling by BMP TGF-beta receptor signaling activates SMADs TGFBR3 PTM regulation TGFBR3 regulates TGF-beta signaling TGFBR3 expression TGFBR3 regulates FGF2 signaling TGFBR3 regulates activin signaling	Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones TGFBR3 regulates activin signaling
Diseases		None	Premature ovarian failure
GWAS		Appendicular lean mass ( 33097823 ) Bone mineral density ( 19249006 ) Carotid plaque burden ( 28282560 ) dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia ( 33002292 ) Gestational age at birth (maternal effect) ( 28877031 ) Glaucoma (primary open-angle) ( 33627673 25861811 ) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Heel bone mineral density ( 30598549 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Lung function (FVC) ( 26635082 30804560 ) Metamizole-induced agranulocytosis or neutropenia ( 33138277 ) Multiple sclerosis ( 31604244 ) Optic disc area ( 25631615 21307088 28073927 31798171 ) Optic disc parameters ( 20548946 ) Optic disc size ( 31809533 ) Optic nerve measurement (cup-to-disc ratio) ( 28061514 ) Peak expiratory flow ( 30804560 ) Pulse pressure ( 30224653 ) QT interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329 ) Type 2 diabetes ( 23209189 ) Vertical cup-disc ratio ( 31798171 28073927 25241763 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	No GWAS studies recorded
Interacting Genes		13 interacting genes: ACVR2A ARRB2 DYNLT4 ENG GIPC1 INHA INHBA NRP1 SDC2 TGFB1 TGFB2 TGFB3 TGFBR2	5 interacting genes: FST INHBA INHBB SIAH1 TGFBR3
Entrez ID		7049	3623
HPRD ID		02846	00933
Ensembl ID		ENSG00000069702	ENSG00000123999
Uniprot IDs		A0A0A8KWK3 Q03167	P05111
PDB IDs		7LBG	Not available
GO Terms Enriched among Interactors		Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Type III Transforming Growth Factor Beta Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Outflow Tract Septum Morphogenesis Gland Morphogenesis Odontogenesis Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Multicellular Organismal Process Heart Development Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Animal Organ Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Developmental Process Activin Binding Response To Growth Factor Growth Factor Activity Negative Regulation Of Macrophage Cytokine Production Cell Surface Receptor Signaling Pathway Animal Organ Development Negative Regulation Of Cytokine Production Secondary Palate Development Anatomical Structure Morphogenesis Artery Morphogenesis Vasculogenesis Positive Regulation Of Cardiocyte Differentiation Transforming Growth Factor Beta Receptor Binding System Development Cardiac Septum Morphogenesis Response To Wounding Roof Of Mouth Development Cytokine Activity	Cardiac Fibroblast Cell Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Gonadotropin Positive Regulation Of Ovulation Negative Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Activin Binding Gonad Development Positive Regulation Of Apoptotic Signaling Pathway Response To Follicle-stimulating Hormone Cellular Response To Cholesterol Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Sterol Reproductive Structure Development Response To Cholesterol Cell Surface Receptor Signaling Pathway Response To Ketone Female Gonad Development Activin Receptor Signaling Pathway Developmental Process Involved In Reproduction Response To Alcohol Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Differentiation Response To Peptide Hormone Positive Regulation Of SMAD Protein Signal Transduction Cardiac Cell Development Ovarian Follicle Development Regulation Of Apoptotic Signaling Pathway Cellular Developmental Process Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Regulation Of Signal Transduction Reproductive Process Erythrocyte Differentiation Positive Regulation Of Reproductive Process Roof Of Mouth Development Hair Cycle Process Animal Organ Development BMP Signaling Pathway Positive Regulation Of Apoptotic Process Extracellular Space Activin A Complex Anatomical Structure Morphogenesis Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Signaling Animal Organ Morphogenesis Negative Regulation Of Cell Communication