TGFBR3 and INHA

Number of citations of the paper that reports this interaction (PMID 10746731)
74

Data Source:
HPRD (in vivo)

		TGFBR3	INHA
Gene Name		transforming growth factor, beta receptor III	inhibin, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Vesicular Exosome	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Inhibin-betaglycan-ActRII Complex Neuronal Cell Body Inhibin A Complex
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Inhibin Binding Protein Heterodimerization Activity
	Biological Process	Blood Vessel Development Response To Hypoxia Blastocyst Development Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Cell Growth Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Regulation Of Protein Binding Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Palate Development Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation	Skeletal System Development Ovarian Follicle Development Cell Cycle Arrest Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Male Gonad Development Response To External Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Erythrocyte Differentiation Regulation Of Cell Proliferation Negative Regulation Of Phosphorylation Hemoglobin Biosynthetic Process Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of B Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Cell Development Regulation Of Cell Cycle SMAD Protein Signal Transduction
Pathways			Peptide hormone metabolism Glycoprotein hormones Peptide hormone biosynthesis
Drugs
Diseases
GWAS		Bone mineral density ( 19249006) Optic disc parameters ( 20548946 21307088) Type 2 diabetes ( 23209189)
Protein-Protein Interactions		13 interactors: ACVR2A ARRB2 ENG GIPC1 INHA INHBA NRP1 SDC2 TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR2	5 interactors: FST INHBA INHBB SIAH1 TGFBR3
Entrez ID		7049	3623
HPRD ID		02846	00933
Ensembl ID		ENSG00000069702	ENSG00000123999
Uniprot IDs		Q03167	P05111
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Response To Wounding Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Cytokine Production Regulation Of Signal Transduction Ovulation Cycle Process Positive Regulation Of Ossification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovulation Cycle Regulation Of Signaling Skeletal System Development Positive Regulation Of Bone Mineralization Wound Healing Regulation Of Cell Differentiation Positive Regulation Of Biomineral Tissue Development Regulation Of MAPK Cascade Salivary Gland Morphogenesis SMAD Protein Import Into Nucleus Cell Growth Salivary Gland Development Negative Regulation Of Cell Proliferation Gland Morphogenesis Response To Organic Substance Negative Regulation Of Immune System Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Negative Regulation Of Signaling Single Organism Reproductive Process Exocrine System Development	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Female Gonad Development Development Of Primary Female Sexual Characteristics Positive Regulation Of Apoptotic Signaling Pathway Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Response To Follicle-stimulating Hormone Gonad Development Development Of Primary Sexual Characteristics Enzyme Linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Reproduction Sex Differentiation Regulation Of Signal Transduction Negative Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Signaling Single Organism Reproductive Process Response To Gonadotropin Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Reproductive Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cell Differentiation Negative Regulation Of Hormone Secretion Ovarian Follicle Development Growth Reproductive Structure Development Reproductive System Development BMP Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Hair Follicle Development Hair Cycle Process Cell Development Ovulation Cycle Process Positive Regulation Of Cell Death System Development Hemopoiesis Positive Regulation Of Hormone Secretion Gamete Generation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Morphogenesis Erythrocyte Differentiation
Tagcloud ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically zfp423	amplification arms choosing codon considering detection fragment is6110 isoniazid katg maba mic minimum mtb multiplex pivotal primers probe qpcr refractory resistant rt snp specificity susceptible taqman thirty zone
Tagcloud (Difference) ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically zfp423	amplification arms choosing codon considering detection fragment is6110 isoniazid katg maba mic minimum mtb multiplex pivotal primers probe qpcr refractory resistant rt snp specificity susceptible taqman thirty zone
Tagcloud (Intersection) ?