TGFBR3 and TCTEX1D4

Number of citations of the paper that reports this interaction (PMID 16982625)
11

Data Source:
HPRD (two hybrid)

		TGFBR3	TCTEX1D4
Gene Name		transforming growth factor, beta receptor III	Tctex1 domain containing 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Vesicular Exosome	Acrosomal Vesicle Nucleus Microtubule Organizing Center Axoneme Sperm Flagellum
	Molecular Function	Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III	Protein Binding
	Biological Process	Blood Vessel Development Response To Hypoxia Blastocyst Development Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Cell Growth Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Regulation Of Protein Binding Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Palate Development Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 19249006) Optic disc parameters ( 20548946 21307088) Type 2 diabetes ( 23209189)
Protein-Protein Interactions		13 interactors: ACVR2A ARRB2 ENG GIPC1 INHA INHBA NRP1 SDC2 TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR2	6 interactors: ACVR2A ENG PPP1CA PPP1CC TGFBR2 TGFBR3
Entrez ID		7049	343521
HPRD ID		02846	15762
Ensembl ID		ENSG00000069702	ENSG00000188396
Uniprot IDs		Q03167	Q5JR98
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Response To Wounding Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Cytokine Production Regulation Of Signal Transduction Ovulation Cycle Process Positive Regulation Of Ossification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovulation Cycle Regulation Of Signaling Skeletal System Development Positive Regulation Of Bone Mineralization Wound Healing Regulation Of Cell Differentiation Positive Regulation Of Biomineral Tissue Development Regulation Of MAPK Cascade Salivary Gland Morphogenesis SMAD Protein Import Into Nucleus Cell Growth Salivary Gland Development Negative Regulation Of Cell Proliferation Gland Morphogenesis Response To Organic Substance Negative Regulation Of Immune System Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Negative Regulation Of Signaling Single Organism Reproductive Process Exocrine System Development	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance BMP Signaling Pathway Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Response To Organic Substance Negative Regulation Of Signaling Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Tissue Morphogenesis Triglyceride Catabolic Process Tissue Development Branching Morphogenesis Of An Epithelial Tube Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Nitric-oxide Synthase Activity Cellular Protein Metabolic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Patterning Of Blood Vessels Anatomical Structure Morphogenesis Embryo Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial Tube Morphogenesis Regulation Of Gene Expression Glycogen Metabolic Process Positive Regulation Of Signal Transduction Tube Morphogenesis Signal Transduction Protein Phosphorylation Organ Regeneration Regulation Of Oxidoreductase Activity
Tagcloud ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically zfp423
Tagcloud (Difference) ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically zfp423
Tagcloud (Intersection) ?