REPS2 and PXN

Number of citations of the paper that reports this interaction (PubMedID 12149250)
0

Data Source:
HPRD (in vitro, in vivo)

		REPS2	PXN
Description		RALBP1 associated Eps domain containing 2	paxillin
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Protein-containing Complex Assembly	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		15 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 ITCH ITSN1 PXN RALB RALBP1 RELA REPS1	86 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN
Entrez ID		9185	5829
HPRD ID		02262	03937
Ensembl ID		ENSG00000169891	ENSG00000089159
Uniprot IDs		Q8NFH8	A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023
PDB IDs		1IQ3	1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0
Enriched GO Terms of Interacting Partners?		Endocytosis Receptor-mediated Endocytosis Import Into Cell Positive Regulation Of Cellular Component Organization Receptor Internalization Clathrin-coated Pit Cytosol Vesicle-mediated Transport Positive Regulation Of Organelle Organization Regulation Of Schwann Cell Differentiation Regulation Of Cellular Component Organization Plasma Membrane Postsynaptic Endocytic Zone Protein-macromolecule Adaptor Activity Cytoplasm Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Signaling Cellular Response To Reactive Oxygen Species SH3 Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Symbiont Entry Into Host Cell Response To Oxidative Stress Regulation Of Signal Transduction Response To Reactive Oxygen Species Biological Process Involved In Interaction With Host Regulation Of Organelle Organization Endosome Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Cytoskeleton Organization Prostate Induction Positive Regulation Of Metabolic Process Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Male Somatic Sex Determination Pronuclear Fusion Cellular Response To Oxidative Stress Centrosome Cycle Positive Regulation Of Cellular Component Biogenesis Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Exocyst Assembly Doxorubicin Transport Transcription Coactivator Binding	Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway
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