REPS2 and EPS15

Number of citations of the paper that reports this interaction (PubMedID 10393179)
0

Data Source:
BioGRID (affinity chromatography technology, far western blotting)
HPRD (in vitro)

		REPS2	EPS15
Description		RALBP1 associated Eps domain containing 2	epidermal growth factor receptor pathway substrate 15
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Early Endosome Membrane Synapse Ciliary Membrane Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Protein-containing Complex Assembly	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Protein Localization Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Clathrin Coat Assembly Ubiquitin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Degradation of CDH1
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)
Interacting Genes		15 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 ITCH ITSN1 PXN RALB RALBP1 RELA REPS1	62 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CDC40 CLINT1 CORO7 CRK DLGAP5 DNM1 DNM2 DRAM1 EGFR ELF3 EPN1 EPN2 FCHO2 GRB2 HGS ITSN1 LAPTM5 LMTK3 MAPK14 MLLT10 MLLT6 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PALMD PICALM PRKN REPS2 RNF11 RNF26 SCAMP1 SH3BP4 SNAP91 SPART SPATA31E1 SPOPL STAM2 STAMBP STON2 SYNJ1 TC2N TFAP2A TMEM114 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 UBQLN3 USP8 WEE1
Entrez ID		9185	2060
HPRD ID		02262	08968
Ensembl ID		ENSG00000169891	ENSG00000085832
Uniprot IDs		Q8NFH8	A0A994J5A3 A0A994J5J3 B7Z240 P42566
PDB IDs		1IQ3	1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?		Endocytosis Receptor-mediated Endocytosis Import Into Cell Positive Regulation Of Cellular Component Organization Receptor Internalization Clathrin-coated Pit Cytosol Vesicle-mediated Transport Positive Regulation Of Organelle Organization Regulation Of Schwann Cell Differentiation Regulation Of Cellular Component Organization Plasma Membrane Postsynaptic Endocytic Zone Protein-macromolecule Adaptor Activity Cytoplasm Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Signaling Cellular Response To Reactive Oxygen Species SH3 Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Symbiont Entry Into Host Cell Response To Oxidative Stress Regulation Of Signal Transduction Response To Reactive Oxygen Species Biological Process Involved In Interaction With Host Regulation Of Organelle Organization Endosome Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Cytoskeleton Organization Prostate Induction Positive Regulation Of Metabolic Process Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Male Somatic Sex Determination Pronuclear Fusion Cellular Response To Oxidative Stress Centrosome Cycle Positive Regulation Of Cellular Component Biogenesis Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Exocyst Assembly Doxorubicin Transport Transcription Coactivator Binding	Endocytosis Clathrin-coated Pit Import Into Cell Clathrin-coated Vesicle Receptor-mediated Endocytosis Vesicle-mediated Transport Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin Coat Assembly Modification-dependent Protein Catabolic Process Vesicle Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Endosome Vesicle Budding From Membrane Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Clathrin Binding Cytoplasmic Vesicle Clathrin Adaptor Activity Membrane Organization Cytosol Intracellular Vesicle Ubiquitin-dependent Protein Catabolic Process Protein Localization To Vacuole Post-translational Protein Modification Protein Ubiquitination Post-Golgi Vesicle-mediated Transport Protein Localization To Lysosome Vacuolar Transport Protein K48-linked Ubiquitination Establishment Of Protein Localization To Vacuole Membrane Coat Macromolecule Catabolic Process Clathrin Vesicle Coat Proteolysis Protein Targeting To Lysosome Cellular Localization Lysosomal Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Modification By Small Protein Conjugation AP-2 Adaptor Complex Endocytic Vesicle Membrane Phosphatidylinositol-4,5-bisphosphate Binding Protein Polyubiquitination Synaptic Vesicle Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process
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