REPS2 and EPS15

Number of citations of the paper that reports this interaction (PMID 10393179)
54

Data Source:
BioGRID (affinity chromatography technology, far western blotting)
HPRD (in vitro)

		REPS2	EPS15
Gene Name		RALBP1 associated Eps domain containing 2	epidermal growth factor receptor pathway substrate 15
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol Plasma Membrane Coated Pit Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane
	Molecular Function	Calcium Ion Binding Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Binding Identical Protein Binding
	Biological Process	Protein Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway	Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Protein Transport Vesicle Organization Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			IgE grass sensitization ( 22036096)
Protein-Protein Interactions		13 interactors: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 PXN RALB RALBP1 RELA REPS1	42 interactors: AGFG1 AGFG2 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 GRB2 HGS ITSN1 ITSN2 LAPTM5 MOB4 NAGPA NEDD4 NUMB NUMBL OPTN PARK2 REPS2 RNF11 SCAMP1 SNAP91 SPG20 STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1
Entrez ID		9185	2060
HPRD ID		02262	08968
Ensembl ID		ENSG00000169891	ENSG00000085832
Uniprot IDs		B4DQQ8 Q8NFH8	B1AUU8 B7Z240 H7BYP0 P42566
PDB IDs		1IQ3	1C07 1EH2 1F8H 1FF1 2IV9 2JXC
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Schwann Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Regulation Of ERBB Signaling Pathway Response To Growth Factor Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Reactive Oxygen Species Cellular Response To Peptide Positive Regulation Of Catalytic Activity Response To Peptide Hormone Response To Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Reactive Oxygen Species Protein Complex Assembly Cellular Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Ras Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Small GTPase Mediated Signal Transduction Negative Regulation Of Signaling Endocytosis Signal Transduction Fc Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor 10 Signaling Pathway Regulation Of Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Insulin Cellular Response To Hydrogen Peroxide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein K48-linked Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Protein Polyubiquitination Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Transport Post-Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Development Establishment Of Localization In Cell Neuron Projection Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neurotrophin Signaling Pathway Intracellular Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Establishment Of Protein Localization Response To Growth Factor Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Cellular Response To Hypoxia Protein Monoubiquitination Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Receptor Internalization Protein Targeting To Lysosome
Tagcloud ?		amphiphysin arrays bioinformatics bridging cytoskeleton differently ectopic endocytosis leaving linking machinery mammals motifs mutagenic partner phage pob1 predictions proline ralbp1 recruiting rich scaffold sh3 spaced traffic transferrin unaffected vesicular	6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Difference) ?		amphiphysin arrays bioinformatics bridging cytoskeleton differently ectopic leaving linking machinery motifs mutagenic partner phage pob1 predictions proline ralbp1 recruiting rich scaffold sh3 spaced traffic transferrin unaffected vesicular	6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 glutathione homology immunoprecipitates immunoreactivity kd keeping metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Intersection) ?		endocytosis mammals