ZW10 and PIAS4

Number of citations of the paper that reports this interaction (PubMedID 20696768)
47

Data Source:
BioGRID (pull down)

		ZW10	PIAS4
Description		zw10 kinetochore protein	protein inhibitor of activated STAT 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Spindle Kinetochore Microtubule Cytosol Cytoskeleton Membrane Dsl1/NZR Complex RZZ Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Transferase Complex
	Molecular Function	Protein Binding Centromeric DNA Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity SUMO Ligase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Mitotic Metaphase Chromosome Alignment Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Exit From Mitosis Protein Transport Vesicle-mediated Transport Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Sumoylation Positive Regulation Of Protein Sumoylation Vitamin D Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of MRNA Stability Negative Regulation Of DNA-templated Transcription Limb Epidermis Development MRNA Destabilization Regulation Of Cellular Response To Stress Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Parental longevity (father's attained age) ( 29227965)	Chronic lymphocytic leukemia ( 28165464) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: APP CEBPA DCTN2 PIAS4 PTF1A RINT1 ZWILCH ZWINT	91 interacting genes: ACTN1 ALDOA AR AREL1 BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G GATA1 HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KNTC1 KPNB1 KRT18 LAMP2 LCE1D LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRKCZ PRPF40A PTN RBBP8 RIF1 RPA2 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNAI2 SNIP1 STIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TOP1 TOP2A TP53 TRIM27 TRIM32 TRIM38 UBE2I UBE2K VHL VIM YY1 ZBTB34 ZHX1 ZNF512B ZW10
Entrez ID		9183	51588
HPRD ID		04902	06910
Ensembl ID		ENSG00000086827	ENSG00000105229
Uniprot IDs		O43264	B3KMR4 Q8N2W9
PDB IDs		7QPG
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Negative Regulation Of Chromosome Organization Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Cycle Phase Transition Homologous Chromosome Orientation In Meiotic Metaphase I Limb Epidermis Development PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Memory Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Chromatin Binding Positive Regulation Of Cell Differentiation DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Ubiquitin Protein Ligase Binding Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Developmental Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?