ZW10 and DCTN2

Number of citations of the paper that reports this interaction (PMID 9700164)
91

Data Source:
HPRD (two hybrid)

		ZW10	DCTN2
Gene Name		zw10 kinetochore protein	dynactin 2 (p50)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Kinetochore Microtubule Cytosol Membrane	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Centromeric DNA Binding	Motor Activity Protein Binding Spectrin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Protein Complex Assembly ER To Golgi Vesicle-mediated Transport Golgi Organization Mitotic Metaphase Plate Congression Mitotic Cell Cycle Checkpoint Regulation Of Exit From Mitosis Meiotic Nuclear Division Protein Transport Protein Localization To Kinetochore Cell Division	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Spindle Organization Mitotic Nuclear Division Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP DCTN2 PTF1A RINT1 UBC ZWILCH ZWINT	21 interactors: BICD1 BICD2 BLOC1S6 CALM1 CCDC172 DISC1 EGFR GADD45A GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MARCKSL1 PAFAH1B1 RPGR ZW10
Entrez ID		9183	10540
HPRD ID		04902	09568
Ensembl ID		ENSG00000086827	ENSG00000175203
Uniprot IDs		A1A528 O43264	Q13561
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Cell Cycle Intracellular Receptor Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Mitotic Nuclear Division Establishment Of Localization In Cell Cell Cycle Process Cellular Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Cycle Regulation Of ERBB Signaling Pathway Regulation Of Cell Cycle Process Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Neural Retina Development Collateral Sprouting Axon Midline Choice Point Recognition Amacrine Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Phase Transition Neuron Remodeling Exocrine Pancreas Development Positive Regulation Of Cell Cycle Antigen Processing And Presentation Positive Regulation Of Proteolysis Viral Protein Processing Regulation Of DNA Damage Checkpoint Regulation Of ER To Golgi Vesicle-mediated Transport	Microtubule-based Process Microtubule Cytoskeleton Organization Cellular Localization Microtubule-based Transport Protein Localization Cytoskeleton-dependent Intracellular Transport Movement Of Cell Or Subcellular Component Microtubule-based Movement Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Protein Localization Organelle Organization Establishment Of Localization In Cell Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Development Cerebral Cortex Development Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Organelle Transport Along Microtubule Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Generation Of Neurons Neuron Differentiation Cytoskeleton Organization Pallium Development Forebrain Development Cell Projection Organization Neurotrophin TRK Receptor Signaling Pathway Brain Development Cellular Response To Mechanical Stimulus Neurogenesis Neurotrophin Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Head Development Neuron Projection Development Nervous System Development Regulation Of ERBB Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Protein Localization To Organelle Cerebral Cortex Cell Migration Fc Receptor Signaling Pathway Cell Cycle Telencephalon Cell Migration Telencephalon Development
Tagcloud ?		apparatus autophagy checkpoint comprises counterpart cytokinesis decay discuss dsl1 dsl3 endoplasmic endosome golgi intercorrelation metazoan moonlighting nag nrz participate reticulum retrograde rint1 sec39 summarize tethering tip20 trafficking transport vesicle
Tagcloud (Difference) ?		apparatus autophagy checkpoint comprises counterpart cytokinesis decay discuss dsl1 dsl3 endoplasmic endosome golgi intercorrelation metazoan moonlighting nag nrz participate reticulum retrograde rint1 sec39 summarize tethering tip20 trafficking transport vesicle
Tagcloud (Intersection) ?