NLRP12 and IRAK1

Number of citations of the paper that reports this interaction (PMID 16203735)
56

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NLRP12	IRAK1
Gene Name		NLR family, pyrin domain containing 12	interleukin-1 receptor-associated kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Lipid Particle Cytosol Plasma Membrane Endosome Membrane Interleukin-1 Receptor Complex
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Ubiquitin-protein Transferase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Heat Shock Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Negative Regulation Of Signal Transduction Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Dendritic Cell Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Interleukin-18 Biosynthetic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of NIK/NF-kappaB Signaling	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Aging Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Heat TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Hypoxia
Pathways			NF-kB is activated and signals survival p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FAF1 IRAK1 PYCARD	49 interactors: AKT1 BCL10 BTK CCDC47 FADD HIST3H3 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 PELI1 PELI2 PELI3 PPP3CB PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 SUMO1 TAB2 TICAM2 TIFA TIRAP TLR2 TLR4 TMEM173 TOLLIP TRAF4 TRAF6 TRIM32 UNC93B1 YTHDC2
Entrez ID		91662	3654
HPRD ID		14803	02235
Ensembl ID		ENSG00000142405	ENSG00000184216
Uniprot IDs		A8MTQ2 B3KTE7 P59046	D3YTB5 P51617
PDB IDs		2L6A
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Interleukin-1 Regulation Of Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Complex Assembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Complex Assembly Response To Molecule Of Bacterial Origin Regulation Of Cellular Protein Metabolic Process Cytoplasmic Sequestering Of NF-kappaB Macropinocytosis Positive Regulation Of Interleukin-6 Secretion Regulation Of Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Lipid Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Chemokine Secretion Response To Bacterium Response To Peptidoglycan	Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Defense Response Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Toll-like Receptor 9 Signaling Pathway Response To Stress I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 5 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 10 Signaling Pathway Signaling Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Signal Transduction Response To Biotic Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Response To Other Organism Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway
Tagcloud ?		agonists antagonizes autoimmunity carboxylic costimulation counteracts decided dipeptide exerted immunomodulatory innovative mediators modify monocytic paediatric pave pdt pidotimod profiler proinflammatory prone prr pyroglutamyl silenced speculated thiaziolidine tlr tlrs upregulates	auc autoimmunity cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tlr tnm toll unclarified valuable
Tagcloud (Difference) ?		agonists antagonizes carboxylic costimulation counteracts decided dipeptide exerted immunomodulatory innovative mediators modify monocytic paediatric pave pdt pidotimod profiler proinflammatory prone prr pyroglutamyl silenced speculated thiaziolidine tlrs upregulates	auc cancerous clinicopathological curve curves distinguish embedded fixed formalin herein lung lymph metastasis microarrays node nsclc operating paraffin receiver roc sclc spearman stream tnm toll unclarified valuable
Tagcloud (Intersection) ?		autoimmunity tlr