NLRP12

Gene Name		NLR family, pyrin domain containing 12
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Negative Regulation Of Signal Transduction Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Dendritic Cell Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Interleukin-18 Biosynthetic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of NIK/NF-kappaB Signaling
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: FAF1 IRAK1 PYCARD
Entrez ID		91662
HPRD ID		14803
Ensembl ID		ENSG00000142405
Uniprot IDs		A8MTQ2 B3KTE7 P59046
PDB IDs		2L6A
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Interleukin-1 Regulation Of Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Complex Assembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Complex Assembly Response To Molecule Of Bacterial Origin Regulation Of Cellular Protein Metabolic Process Cytoplasmic Sequestering Of NF-kappaB Macropinocytosis Positive Regulation Of Interleukin-6 Secretion Regulation Of Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Lipid Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Chemokine Secretion Response To Bacterium Response To Peptidoglycan
Tagcloud ?		agonists antagonizes autoimmunity carboxylic costimulation counteracts decided dipeptide exerted immunomodulatory innovative mediators modify monocytic paediatric pave pdt pidotimod profiler proinflammatory prone prr pyroglutamyl silenced speculated thiaziolidine tlr tlrs upregulates