NLRP12 and PYCARD

Number of citations of the paper that reports this interaction (PMID 12019269)
68

Data Source:
HPRD (in vivo)

		NLRP12	PYCARD
Gene Name		NLR family, pyrin domain containing 12	PYD and CARD domain containing
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Nucleus Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process	Protease Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pyrin Domain Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Negative Regulation Of Signal Transduction Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Dendritic Cell Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Interleukin-18 Biosynthetic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of NIK/NF-kappaB Signaling	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Rac GTPase Activity Interleukin-1 Beta Production Negative Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Chemokine Secretion Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			The NLRP3 inflammasome Inflammasomes The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FAF1 IRAK1 PYCARD	11 interactors: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF
Entrez ID		91662	29108
HPRD ID		14803	06020
Ensembl ID		ENSG00000142405	ENSG00000103490
Uniprot IDs		A8MTQ2 B3KTE7 P59046	Q9ULZ3
PDB IDs		2L6A	1UCP 2KN6
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Interleukin-1 Regulation Of Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Complex Assembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Complex Assembly Response To Molecule Of Bacterial Origin Regulation Of Cellular Protein Metabolic Process Cytoplasmic Sequestering Of NF-kappaB Macropinocytosis Positive Regulation Of Interleukin-6 Secretion Regulation Of Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Lipid Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Chemokine Secretion Response To Bacterium Response To Peptidoglycan	Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cytokine Secretion Regulation Of Endopeptidase Activity Regulation Of Protein Secretion Immune System Process Regulation Of Peptidase Activity Innate Immune Response Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Interleukin-1 Beta Production Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Cytokine Production Positive Regulation Of Hydrolase Activity Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Transport Regulation Of Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion Positive Regulation Of Protein Transport Immune Response Positive Regulation Of Cytokine Production Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		agonists antagonizes autoimmunity carboxylic costimulation counteracts decided dipeptide exerted immunomodulatory innovative mediators modify monocytic paediatric pave pdt pidotimod profiler proinflammatory prone prr pyroglutamyl silenced speculated thiaziolidine tlr tlrs upregulates	1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nlrp3 nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover
Tagcloud (Difference) ?		agonists antagonizes autoimmunity carboxylic costimulation counteracts decided dipeptide exerted immunomodulatory innovative mediators modify monocytic paediatric pave pdt pidotimod profiler proinflammatory prone prr pyroglutamyl silenced speculated thiaziolidine tlr tlrs upregulates	1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nlrp3 nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover
Tagcloud (Intersection) ?