NEXN and TRIM15

Number of citations of the paper that reports this interaction (PubMedID 25450970)
0

Data Source:
BioGRID (protein complementation assay)

		NEXN	TRIM15
Description		nexilin F-actin binding protein	tripartite motif containing 15
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Axon Anchoring Junction	Nucleus Cytoplasm Focal Adhesion Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding Cell-cell Adhesion Mediator Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Regulation Of Cell Migration Regulation Of Cytoskeleton Organization Dendrite Self-avoidance	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material
Pathways
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung cancer in never smokers ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)
Interacting Genes		11 interacting genes: ACTA1 CALM1 FAM107A FXR2 HMGB1 HMGB2 HSPB1 SIRPA TRIM15 ZNF250 ZSCAN22	42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2
Entrez ID		91624	89870
HPRD ID		11388	15551
Ensembl ID		ENSG00000162614	ENSG00000204610
Uniprot IDs		B4DDI0 Q0ZGT2	Q5SRL0 Q9C019
PDB IDs			7QS2
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Supercoiled DNA Binding Regulation Of Interferon-beta Production DNA Geometric Change DNA Topological Change RAGE Receptor Binding Positive Regulation Of Type I Interferon Production Regulation Of Interleukin-1 Beta Production Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Production DNA Binding, Bending Four-way Junction DNA Binding DNA Conformation Change V(D)J Recombination Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phagocytosis Regulation Of Cytokine Production Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Synaptic Plasticity Regulation Of Cell Communication Regulation Of Signaling Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Chemoattractant Activity Regulation Of Tumor Necrosis Factor Production Condensed Chromosome Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Interferon-beta Production Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Somatic Cell DNA Recombination Positive Chemotaxis Sarcomere Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Beta Production Transcription Coactivator Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Process Damaged DNA Binding Positive Regulation Of Innate Immune Response Negative Regulation Of Endocytosis Cellular Response To Type II Interferon Positive Regulation Of Interleukin-1 Production	Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion
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