NEXN and FXR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NEXN	FXR2
Description		nexilin F-actin binding protein	FMR1 autosomal homolog 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Axon Anchoring Junction	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Synapse Presynapse Postsynapse
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding Cell-cell Adhesion Mediator Activity	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Regulation Of Cell Migration Regulation Of Cytoskeleton Organization Dendrite Self-avoidance	Regulation Of Translation Dentate Gyrus Development Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung cancer in never smokers ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Monocyte count ( 32888494) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)
Interacting Genes		11 interacting genes: ACTA1 CALM1 FAM107A FXR2 HMGB1 HMGB2 HSPB1 SIRPA TRIM15 ZNF250 ZSCAN22	191 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PRPF6 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RPS2 RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SRPK2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 USP39 VIM WDR59 WEE2-AS1 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1
Entrez ID		91624	9513
HPRD ID		11388	05629
Ensembl ID		ENSG00000162614	ENSG00000129245
Uniprot IDs		B4DDI0 Q0ZGT2	P51116
PDB IDs			3H8Z
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Supercoiled DNA Binding Regulation Of Interferon-beta Production DNA Geometric Change DNA Topological Change RAGE Receptor Binding Positive Regulation Of Type I Interferon Production Regulation Of Interleukin-1 Beta Production Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Production DNA Binding, Bending Four-way Junction DNA Binding DNA Conformation Change V(D)J Recombination Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phagocytosis Regulation Of Cytokine Production Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Synaptic Plasticity Regulation Of Cell Communication Regulation Of Signaling Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Chemoattractant Activity Regulation Of Tumor Necrosis Factor Production Condensed Chromosome Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Interferon-beta Production Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Somatic Cell DNA Recombination Positive Chemotaxis Sarcomere Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Beta Production Transcription Coactivator Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Process Damaged DNA Binding Positive Regulation Of Innate Immune Response Negative Regulation Of Endocytosis Cellular Response To Type II Interferon Positive Regulation Of Interleukin-1 Production	Identical Protein Binding Protein Binding Cytoplasm Cytosol Cytoskeleton Negative Regulation Of RNA Metabolic Process Neuron Projection MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Establishment Of Mitotic Spindle Orientation Paraspeckles Nucleoplasm Regulation Of RNA Metabolic Process Centrosome Regulation Of Neurotrophin TRK Receptor Signaling Pathway MRNA Binding Negative Regulation Of DNA-templated Transcription Establishment Of Mitotic Spindle Localization Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Metabolic Process Establishment Of Spindle Orientation Microtubule-based Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Regulation Of MRNA Metabolic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Dendritic Spine Development RNA Binding Signaling Adaptor Activity Negative Regulation Of Metabolic Process Establishment Of Spindle Localization Negative Regulation Of Centriole Replication Intracellular Membraneless Organelle Establishment Of Organelle Localization Protein Domain Specific Binding Spindle Localization Regulation Of DNA-templated Transcription Regulation Of Cell Projection Organization Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Dendritic Spine Development Endoplasmic Reticulum Tubular Network Membrane Organization System Development
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