NEXN and FAM107A

Number of citations of the paper that reports this interaction (PubMedID 28604741)
0

Data Source:
BioGRID (two hybrid)

		NEXN	FAM107A
Description		nexilin F-actin binding protein	family with sequence similarity 107 member A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Axon Anchoring Junction	Stress Fiber Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Nuclear Speck Ruffle Membrane Cell Projection Neuron Projection Synapse Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding Cell-cell Adhesion Mediator Activity	Actin Binding Protein Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Regulation Of Cell Migration Regulation Of Cytoskeleton Organization Dendrite Self-avoidance	Regulation Of Cell Growth Actin Filament Polymerization Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Regulation Of Actin Cytoskeleton Organization Cognition Actin Filament Bundle Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Glucocorticoid Stimulus Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung cancer in never smokers ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917)
Interacting Genes		11 interacting genes: ACTA1 CALM1 FAM107A FXR2 HMGB1 HMGB2 HSPB1 SIRPA TRIM15 ZNF250 ZSCAN22	58 interacting genes: AGMAT APPBP2 AUH AZI2 BEGAIN BIRC8 CALCOCO2 CANX CCDC125 CCDC136 CCDC57 CCDC85B CPSF3 DAPK1 EFEMP2 EFHC2 EIF4A1 ESRRG FKBP6 FSD2 GFM2 GOLGA6L9 HFM1 HOOK2 HSF2BP HSPA14 HSPD1 HTRA1 IQUB ITPRID2 KRT15 KRT19 KRT27 KRT40 KRTAP4-12 LDOC1 LZTS2 MEIOB MID2 MTREX MTUS2 NEXN NFKBID NINL PLSCR1 PNMA1 POMP PSMD6 RAB18 RINT1 RNLS SPATA22 TADA2A TRAF2 TRIM37 USHBP1 VIM WDR47
Entrez ID		91624	11170
HPRD ID		11388	09753
Ensembl ID		ENSG00000162614	ENSG00000168309
Uniprot IDs		B4DDI0 Q0ZGT2	O95990 Q6IAM1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Supercoiled DNA Binding Regulation Of Interferon-beta Production DNA Geometric Change DNA Topological Change RAGE Receptor Binding Positive Regulation Of Type I Interferon Production Regulation Of Interleukin-1 Beta Production Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Production DNA Binding, Bending Four-way Junction DNA Binding DNA Conformation Change V(D)J Recombination Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phagocytosis Regulation Of Cytokine Production Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Synaptic Plasticity Regulation Of Cell Communication Regulation Of Signaling Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Chemoattractant Activity Regulation Of Tumor Necrosis Factor Production Condensed Chromosome Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Interferon-beta Production Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Somatic Cell DNA Recombination Positive Chemotaxis Sarcomere Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Beta Production Transcription Coactivator Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Process Damaged DNA Binding Positive Regulation Of Innate Immune Response Negative Regulation Of Endocytosis Cellular Response To Type II Interferon Positive Regulation Of Interleukin-1 Production	Cytoskeleton Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Microtubule Structural Constituent Of Skin Epidermis Meiosis I Cell Cycle Process Female Meiosis I Supramolecular Fiber Organization
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