MAT2A and CUL3

Number of citations of the paper that reports this interaction (PubMedID 21145461)
29

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		MAT2A	CUL3
Description		methionine adenosyltransferase 2A	cullin 3
Image
GO Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Motile Cilium Sperm Flagellum Cell Projection Extracellular Exosome Mitotic Spindle Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Methionine Adenosyltransferase Activity Protein Binding ATP Binding Transferase Activity Small Molecule Binding Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Protein-containing Complex Localization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein Hexamerization TORC1 Signaling Protein Complex Oligomerization Protein Heterooligomerization Cellular Response To Methionine Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leukemia Inhibitory Factor	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitotic Cell Cycle Cell Morphogenesis In Utero Embryonic Development Kidney Development Trophectodermal Cellular Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Response To Stress Inflammatory Response Response To Oxidative Stress Mitotic Metaphase Chromosome Alignment Signal Transduction Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Wnt Signaling Pathway Vesicle-mediated Transport Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Nutrient Levels Positive Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Cell Division Protein Autoubiquitination Type I Interferon-mediated Signaling Pathway Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Regulation Of Primary Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Postsynapse RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Methylation	Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RHOBTB3 ATPase cycle KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs		Ademetionine
Diseases
GWAS		Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Myocardial infarction ( 33532862) Urinary albumin excretion ( 30220432)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 25056061 28991256 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		10 interacting genes: CEBPA CUL3 DSCAM HGS MAT1A MAT2B OGT PRC1 TMEM213 UBE2I	66 interacting genes: ABTB1 ABTB2 ARHGEF12 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CEBPA CLK1 COMMD1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 FOLR1 GABARAP GABARAPL1 GABARAPL2 GLUD1 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD7 KLHL12 KLHL22 KLHL42 KLHL6 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDIA2 PDPK1 RBBP8 RBX1 RCBTB1 RHOBTB3 RIT1 RNF7 SHKBP1 SNX6 SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 WNT7B ZMAT4
Entrez ID		4144	8452
HPRD ID		03275	09123
Ensembl ID		ENSG00000168906	ENSG00000036257
Uniprot IDs		A0A140VJP5 P31153	B7Z600 Q13618
PDB IDs		2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R 6P9V 6WKB 7BHR 7BHS 7BHT 7BHU 7BHV 7BHW 7BHX 7KCC 7KCE 7KCF 7KDA 7KDB 7L1A 7LNH 7RW5 7RW7 7RWG 7RWH 7RXV 7RXW 7RXX 8AXZ 8OOG 8P1T 8P1V 8P1W 8P4H 8QDY 8QDZ 8QE0 8QE1 8QE2 8QE3 8XAM 8XAR 8XB0 8XJ2	2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8I79 8K8T 8K9I 8KHP 8U80 8U81 8U82 8U83 8U84
Enriched GO Terms of Interacting Partners?		Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process S-adenosylmethionine Metabolic Process Cellular Component Assembly One-carbon Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding L-methionine Catabolic Process Methionine Adenosyltransferase Activity SUMO Conjugating Enzyme Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of Cytokinesis Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic Spindle Elongation Methionine Adenosyltransferase Regulator Activity Protein Localization To Vacuole CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Sulfur Compound Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Protein Catabolic Process At Postsynapse Regulation Of TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Phenylpropanoid Response To Nutrient Levels Positive Regulation Of Gene Expression Inflammatory Response Response To Nutrient White Fat Cell Proliferation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Phosphorus Metabolic Process Catabolic Process SUMO Ligase Complex Small Protein Activating Enzyme Binding Cell Division	Protein Modification By Small Protein Conjugation Protein Neddylation Post-translational Protein Modification Cellular Response To Nitrogen Starvation Protein Modification Process Cullin Family Protein Binding Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Phosphatidylethanolamine Binding Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Neddylation Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Mitophagy Protein K48-linked Ubiquitination Protein Tag Activity Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Starvation Ubiquitin-protein Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Autophagosome Maturation Protein Metabolic Process Protein Polyubiquitination Cytoplasm Autophagosome Assembly Autophagosome Membrane Response To Starvation Autophagosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Binding Ubiquitin Conjugating Enzyme Binding Macromolecule Catabolic Process Autophagosome Proteasomal Protein Catabolic Process Nucleus Mitotic Cell Cycle Phase Transition GABA Receptor Binding Cytosol Macroautophagy
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