MAT2A and TMEM213

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MAT2A	TMEM213
Description		methionine adenosyltransferase 2A	transmembrane protein 213
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex	Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Methionine Adenosyltransferase Activity Protein Binding ATP Binding Transferase Activity Small Molecule Binding Identical Protein Binding Metal Ion Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Protein-containing Complex Localization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein Hexamerization TORC1 Signaling Protein Complex Oligomerization Protein Heterooligomerization Cellular Response To Methionine Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leukemia Inhibitory Factor
Pathways		Methylation
Drugs		Ademetionine
Diseases
GWAS		Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Myocardial infarction ( 33532862) Urinary albumin excretion ( 30220432)
Interacting Genes		10 interacting genes: CEBPA CUL3 DSCAM HGS MAT1A MAT2B OGT PRC1 TMEM213 UBE2I	4 interacting genes: MAL MAT2A PGRMC1 TCF4
Entrez ID		4144	155006
HPRD ID		03275	19298
Ensembl ID		ENSG00000168906	ENSG00000214128
Uniprot IDs		A0A140VJP5 P31153	A2RRL7
PDB IDs		2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R 6P9V 6WKB 7BHR 7BHS 7BHT 7BHU 7BHV 7BHW 7BHX 7KCC 7KCE 7KCF 7KDA 7KDB 7L1A 7LNH 7RW5 7RW7 7RWG 7RWH 7RXV 7RXW 7RXX 8AXZ 8OOG 8P1T 8P1V 8P1W 8P4H 8QDY 8QDZ 8QE0 8QE1 8QE2 8QE3 8XAM 8XAR 8XB0 8XJ2
Enriched GO Terms of Interacting Partners?		Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process S-adenosylmethionine Metabolic Process Cellular Component Assembly One-carbon Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding L-methionine Catabolic Process Methionine Adenosyltransferase Activity SUMO Conjugating Enzyme Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of Cytokinesis Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic Spindle Elongation Methionine Adenosyltransferase Regulator Activity Protein Localization To Vacuole CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Sulfur Compound Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Protein Catabolic Process At Postsynapse Regulation Of TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Phenylpropanoid Response To Nutrient Levels Positive Regulation Of Gene Expression Inflammatory Response Response To Nutrient White Fat Cell Proliferation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Phosphorus Metabolic Process Catabolic Process SUMO Ligase Complex Small Protein Activating Enzyme Binding Cell Division	Protein Localization To Paranode Region Of Axon Protein Insertion Into Plasma Membrane Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Methionine Adenosyltransferase Activity Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Peptidase Activator Activity Involved In Apoptotic Process Positive Regulation Of Lipoprotein Transport Cellular Response To Methionine Membrane Raft Distribution Response To Methionine Membrane Raft Localization Smooth Endoplasmic Reticulum Membrane Protein Localization To Axon Lipid Binding Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath S-adenosylmethionine Metabolic Process Protein Hexamerization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Beta-catenin-TCF Complex Apical Protein Localization Negative Regulation Of Synapse Organization One-carbon Metabolic Process Heme Biosynthetic Process Modification Of Synaptic Structure Small Molecule Binding Membrane Raft Organization Protein Heterooligomerization Tetrapyrrole Biosynthetic Process Steroid Binding Porphyrin-containing Compound Biosynthetic Process
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