MAT2A and TMEM213

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MAT2A	TMEM213
Gene Name		methionine adenosyltransferase II, alpha	transmembrane protein 213
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex	Integral Component Of Membrane
	Molecular Function	Methionine Adenosyltransferase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		S-Adenosylmethionine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: HGS MAT2B TMEM213	2 interactors: MAT2A TCF4
Entrez ID		4144	155006
HPRD ID		03275	19298
Ensembl ID		ENSG00000168906	ENSG00000214128
Uniprot IDs		P31153	A2RRL7
PDB IDs		2P02
Enriched GO Terms of Interacting Partners?		S-adenosylmethionine Biosynthetic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Protein Localization To Lysosome S-adenosylmethionine Metabolic Process Membrane Invagination Negative Regulation Of JAK-STAT Cascade Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Endosome To Lysosome Transport Lysosomal Transport One-carbon Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Exocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Regulation Of JAK-STAT Cascade	Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Maintenance Of DNA Repeat Elements S-adenosylmethionine Biosynthetic Process Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Myoblast Fate Commitment Secretory Granule Localization Hindgut Morphogenesis Insulin Metabolic Process Hindgut Development Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process S-adenosylmethionine Metabolic Process Positive Regulation Of Gluconeogenesis Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Digestive Tract Morphogenesis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Protein Export From Nucleus Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Glucose Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Hormone Metabolic Process Face Morphogenesis Negative Regulation Of Organ Growth Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Head Morphogenesis Oligodendrocyte Development Embryonic Digestive Tract Development Negative Regulation Of BMP Signaling Pathway Regulation Of Oligodendrocyte Differentiation One-carbon Metabolic Process Myoblast Differentiation Regulation Of Gluconeogenesis Bone Mineralization Regulation Of Myelination Face Development Positive Regulation Of Stem Cell Differentiation Pituitary Gland Development Regulation Of Epithelial To Mesenchymal Transition Genitalia Development Negative Regulation Of Fat Cell Differentiation Body Morphogenesis Positive Regulation Of Lipid Biosynthetic Process
Tagcloud ?		adenosylmethionine carcinogen compensate deregulation focuses forced hcc hepatocarcinogenesis hypomethylation instability isozyme isozymes lkb1 macrovesicular mat1a mati matii mats microvascularization periportal pleiotropic polyamine predicts rodent sam steatosis switch synthesizing upregulation
Tagcloud (Difference) ?		adenosylmethionine carcinogen compensate deregulation focuses forced hcc hepatocarcinogenesis hypomethylation instability isozyme isozymes lkb1 macrovesicular mat1a mati matii mats microvascularization periportal pleiotropic polyamine predicts rodent sam steatosis switch synthesizing upregulation
Tagcloud (Intersection) ?