MAT2A and PRC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAT2A	PRC1
Description		methionine adenosyltransferase 2A	protein regulator of cytokinesis 1
Image
GO Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone
	Molecular Function	Nucleotide Binding Methionine Adenosyltransferase Activity Protein Binding ATP Binding Transferase Activity Small Molecule Binding Identical Protein Binding Metal Ion Binding	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Protein-containing Complex Localization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein Hexamerization TORC1 Signaling Protein Complex Oligomerization Protein Heterooligomerization Cellular Response To Methionine Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leukemia Inhibitory Factor	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division
Pathways		Methylation	RHO GTPases activate CIT
Drugs		Ademetionine
Diseases
GWAS		Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Myocardial infarction ( 33532862) Urinary albumin excretion ( 30220432)	Breast cancer ( 25038754 29059683) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 31194737 33830993) Red cell distribution width ( 32888494) Type 2 diabetes ( 20581827 22885922 24509480 26818947 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		10 interacting genes: CEBPA CUL3 DSCAM HGS MAT1A MAT2B OGT PRC1 TMEM213 UBE2I	43 interacting genes: AKAP9 BICD2 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CEBPA CINP EMG1 EXOSC7 EXOSC8 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 LARP4 MAT2A NDEL1 NUDT16 OGT PBK PCM1 PKIA PLK1 PPIE RACGAP1 RBM10 RBM17 RBM22 RPA2 SF3B2 SLAIN1 SUMO2 TFIP11 THOC1 TRIM37 USHBP1 YWHAE
Entrez ID		4144	9055
HPRD ID		03275	17899
Ensembl ID		ENSG00000168906	ENSG00000198901
Uniprot IDs		A0A140VJP5 P31153	O43663
PDB IDs		2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R 6P9V 6WKB 7BHR 7BHS 7BHT 7BHU 7BHV 7BHW 7BHX 7KCC 7KCE 7KCF 7KDA 7KDB 7L1A 7LNH 7RW5 7RW7 7RWG 7RWH 7RXV 7RXW 7RXX 8AXZ 8OOG 8P1T 8P1V 8P1W 8P4H 8QDY 8QDZ 8QE0 8QE1 8QE2 8QE3 8XAM 8XAR 8XB0 8XJ2	3NRX 3NRY 4L3I 4L6Y 5KMG 7VBG
Enriched GO Terms of Interacting Partners?		Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process S-adenosylmethionine Metabolic Process Cellular Component Assembly One-carbon Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding L-methionine Catabolic Process Methionine Adenosyltransferase Activity SUMO Conjugating Enzyme Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of Cytokinesis Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic Spindle Elongation Methionine Adenosyltransferase Regulator Activity Protein Localization To Vacuole CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Sulfur Compound Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Protein Catabolic Process At Postsynapse Regulation Of TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Phenylpropanoid Response To Nutrient Levels Positive Regulation Of Gene Expression Inflammatory Response Response To Nutrient White Fat Cell Proliferation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Phosphorus Metabolic Process Catabolic Process SUMO Ligase Complex Small Protein Activating Enzyme Binding Cell Division	Microtubule-based Process Nucleic Acid Metabolic Process Organelle Organization Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Cell Cycle G2/M Phase Transition Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cytoplasm G1/S Transition Of Mitotic Cell Cycle Regulation Of Intracellular Protein Transport MRNA Metabolic Process Cell Cycle G1/S Phase Transition Nucleoplasm Nucleus Cell Cycle Phase Transition Centrosome Separation Centrosome Spindle Microtubule Microtubule Organizing Center RNA Metabolic Process Regulation Of Intracellular Transport Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Kinesin Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process RNA Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleocytoplasmic Transport RNA Splicing, Via Transesterification Reactions Cell Division Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Damage Checkpoint Signaling
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