MAT2A

Gene Name		methionine adenosyltransferase II, alpha
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Gene Ontology Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex
	Molecular Function	Methionine Adenosyltransferase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		S-Adenosylmethionine
Diseases
GWAS
Protein-protein Interactions		3 interactors: HGS MAT2B TMEM213
Entrez ID		4144
HPRD ID		03275
Ensembl ID		ENSG00000168906
Uniprot IDs		P31153
PDB IDs		2P02
Enriched GO Terms of Interacting Partners?		S-adenosylmethionine Biosynthetic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Protein Localization To Lysosome S-adenosylmethionine Metabolic Process Membrane Invagination Negative Regulation Of JAK-STAT Cascade Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Endosome To Lysosome Transport Lysosomal Transport One-carbon Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Exocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Regulation Of JAK-STAT Cascade
Tagcloud ?		adenosylmethionine carcinogen compensate deregulation focuses forced hcc hepatocarcinogenesis hypomethylation instability isozyme isozymes lkb1 macrovesicular mat1a mati matii mats microvascularization periportal pleiotropic polyamine predicts rodent sam steatosis switch synthesizing upregulation