MAT2A and MAT2B

Number of citations of the paper that reports this interaction (PMID 12671891)
21

Data Source:
HPRD (in vivo)

		MAT2A	MAT2B
Gene Name		methionine adenosyltransferase II, alpha	methionine adenosyltransferase II, beta
Image
Gene Ontology Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex	Intracellular Nucleus Mitochondrion Cytosol Methionine Adenosyltransferase Complex Extracellular Vesicular Exosome
	Molecular Function	Methionine Adenosyltransferase Activity Protein Binding ATP Binding Metal Ion Binding	Enzyme Binding Methionine Adenosyltransferase Regulator Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process Regulation Of Catalytic Activity
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		S-Adenosylmethionine
Diseases
GWAS			Aging ( 22773346) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		3 interactors: HGS MAT2B TMEM213	6 interactors: APP FBXO25 KPNA3 KPNA4 MAT2A TRIM27
Entrez ID		4144	27430
HPRD ID		03275	05701
Ensembl ID		ENSG00000168906	ENSG00000038274
Uniprot IDs		P31153	Q9NZL9
PDB IDs		2P02	2YDX 2YDY
Enriched GO Terms of Interacting Partners?		S-adenosylmethionine Biosynthetic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Protein Localization To Lysosome S-adenosylmethionine Metabolic Process Membrane Invagination Negative Regulation Of JAK-STAT Cascade Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Endosome To Lysosome Transport Lysosomal Transport One-carbon Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Exocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Regulation Of JAK-STAT Cascade	NLS-bearing Protein Import Into Nucleus Intracellular Transport Protein Import Into Nucleus Nuclear Import Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus Protein Import Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Protein Localization To Nucleus Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization S-adenosylmethionine Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Axon Choice Point Recognition Nucleocytoplasmic Transport Nuclear Transport Interferon-gamma Secretion Neuron Remodeling Establishment Of Protein Localization To Organelle
Tagcloud ?		adenosylmethionine carcinogen compensate deregulation focuses forced hcc hepatocarcinogenesis hypomethylation instability isozyme isozymes lkb1 macrovesicular mat1a mati matii mats microvascularization periportal pleiotropic polyamine predicts rodent sam steatosis switch synthesizing upregulation	adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified
Tagcloud (Difference) ?		adenosylmethionine carcinogen compensate deregulation focuses forced hcc hepatocarcinogenesis hypomethylation instability isozyme isozymes lkb1 macrovesicular mat1a mati matii mats microvascularization periportal pleiotropic polyamine predicts rodent sam steatosis switch synthesizing upregulation	adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified
Tagcloud (Intersection) ?