RHOBTB3 and CUL3

Number of citations of the paper that reports this interaction (PMID 24145166)
1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RHOBTB3	CUL3
Gene Name		Rho-related BTB domain containing 3	cullin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Extracellular Vesicular Exosome	Golgi Membrane Nucleoplasm Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding GTP Binding ATPase Activity Rab GTPase Binding	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Small GTPase Mediated Signal Transduction Metabolic Process Retrograde Transport, Endosome To Golgi	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Cell Cycle Arrest Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog degradation of DVL Class I MHC mediated antigen processing & presentation Signaling by WNT in cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BHLHE40 CCNE1 CUL3 HGS RAB9A RBPMS RBX1 RHOBTB2 UBXN11	54 interactors: ABTB1 ABTB2 APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 COMMD1 DCUN1D1 DCUN1D4 DYRK4 EFNB1 FOLR1 GMCL1 GPS1 HLA-DMB HSF2 KCTD13 KCTD5 KCTD6 KCTD9 KLHL12 KLHL2 KLHL20 KLHL3 KLHL42 KLHL5 NEDD8 OLIG2 PDIA2 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SUMO2 SUMO3 TCEB1 TNFAIP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2M WNT7B ZMAT4
Entrez ID		22836	8452
HPRD ID		09557	09123
Ensembl ID		ENSG00000164292	ENSG00000036257
Uniprot IDs		O94955	B7Z600 Q13618
PDB IDs			4AP2 4APF 4EOZ 4HXI
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Monoubiquitination Positive Regulation Of Exocytosis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Trophectodermal Cellular Morphogenesis Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Exocytosis G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Transport Negative Regulation Of Wnt Signaling Pathway Endosomal Transport Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Wnt Signaling Pathway Embryonic Cleavage Signal Transduction Positive Regulation Of SMAD Protein Import Into Nucleus Protein Localization To Lysosome Stress Fiber Assembly Regulation Of Wnt Signaling Pathway Regulation Of Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Chromosome Segregation Positive Regulation Of Secretion Negative Regulation Of Signal Transduction Regulation Of SMAD Protein Import Into Nucleus Membrane Invagination COPII Vesicle Coating Signaling Negative Regulation Of Signaling Cell Communication Regulation Of Vesicle-mediated Transport Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Targeting To Vacuole	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Neddylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Monoubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Homooligomerization Protein K11-linked Ubiquitination Proteolysis Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Oligomerization Response To Growth Factor Regulation Of Cellular Process Protein Complex Assembly DNA Replication Cellular Response To Stress Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tubules tunica ubiquitous ubiquitously uterus vesicle	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Difference) ?		apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tubules tunica ubiquitous ubiquitously uterus vesicle	besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2
Tagcloud (Intersection) ?