RHOBTB3 and RHOBTB2

Number of citations of the paper that reports this interaction (PubMedID 18835386)
43

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RHOBTB3	RHOBTB2
Description		Rho related BTB domain containing 3	Rho related BTB domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Trans-Golgi Network Membrane Extracellular Exosome	Cytoskeleton Plasma Membrane Endosome Membrane Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Small GTPase Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Male Gonad Development Regulation Of Proteolysis Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Protein Ubiquitination Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		Retrograde transport at the Trans-Golgi-Network RHOBTB3 ATPase cycle	RHOBTB2 GTPase cycle
Drugs
Diseases
GWAS			Alzheimer's disease progression score ( 29860282) Aspartate aminotransferase levels ( 33547301) Basal cell carcinoma ( 33549134) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)
Interacting Genes		18 interacting genes: BHLHE40 CCNE1 CUL3 EFHC2 HGS IHO1 L3MBTL3 PLAGL2 RAB9A RBPMS RBX1 RHOBTB2 RIPPLY3 SNCA TBX15 UBXN11 USP54 VHL	12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11
Entrez ID		22836	23221
HPRD ID		09557	06300
Ensembl ID		ENSG00000164292	ENSG00000008853
Uniprot IDs		O94955	Q9BYZ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Molecular Adaptor Activity Negative Regulation Of TORC1 Signaling Cul3-RING Ubiquitin Ligase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of RNA Biosynthetic Process Positive Regulation Of Exocytosis Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Autophagy Negative Regulation Of Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Modification-dependent Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Renal Sodium Ion Transport Regulation Of Nucleobase-containing Compound Metabolic Process Homologous Chromosome Pairing At Meiosis Regulation Of Transcription By RNA Polymerase II Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Amyloid Fibril Formation Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress Regulation Of TOR Signaling Proteolysis Involved In Protein Catabolic Process Regulation Of Gene Expression Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nuclear RNA Surveillance Regulation Of Macromolecule Biosynthetic Process Receptor-mediated Endocytosis RNA Surveillance Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Ubiquitin Protein Ligase Binding Cellular Response To Stress Response To Stress ATP Binding Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Protein Localization Protein Metabolic Process Protein Stabilization Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To Unfolded Protein Protein Dephosphorylation Cellular Response To Growth Factor Stimulus Protein Modification Process Signal Transduction By P53 Class Mediator Regulation Of Protein Modification Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding Response To Growth Factor Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Protein Autophosphorylation Negative Regulation Of Cell Population Proliferation Dephosphorylation Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase Regulation Of Protein Stability DNA Polymerase Binding Phosphorylation ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Axonal Growth Cone RNA-templated DNA Biosynthetic Process Mitotic Cell Cycle Phase Transition Phosphate-containing Compound Metabolic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Cell Cycle Phase Transition Negative Regulation Of Apoptotic Process Myelin Sheath Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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