RHOBTB3 and CCNE1

Number of citations of the paper that reports this interaction (PMID 24145166)
1

Data Source:
BioGRID (enzymatic study)

		RHOBTB3	CCNE1
Gene Name		Rho-related BTB domain containing 3	cyclin E1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Extracellular Vesicular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding GTP Binding ATPase Activity Rab GTPase Binding	Transcription Coactivator Activity Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Androgen Receptor Binding
	Biological Process	Small GTPase Mediated Signal Transduction Metabolic Process Retrograde Transport, Endosome To Golgi	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Protein Phosphorylation Wnt Signaling Pathway Androgen Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cell Division Regulation Of Cell Cycle
Pathways			E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS			Bladder cancer ( 20972438)
Protein-Protein Interactions		9 interactors: BHLHE40 CCNE1 CUL3 HGS RAB9A RBPMS RBX1 RHOBTB2 UBXN11	46 interactors: AR ARHGEF5 ARID4A BRCA2 BTRC CABLES1 CALM1 CCT4 CDC25A CDC34 CDC6 CDK1 CDK2 CDK3 CDKN1A COIL CUL3 FBXW7 FOXM1 GSK3B H1F0 HERC5 HIST1H1A HIST1H1B MARCKS MCM3 MRE11A MYBL2 NBN PIN1 POLD1 PRC1 PRKAR1A RB1 RBL1 RBL2 RBX1 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 TP73 UBTF
Entrez ID		22836	898
HPRD ID		09557	00455
Ensembl ID		ENSG00000164292	ENSG00000105173
Uniprot IDs		O94955	P24864
PDB IDs			1W98
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Monoubiquitination Positive Regulation Of Exocytosis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Trophectodermal Cellular Morphogenesis Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Exocytosis G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Transport Negative Regulation Of Wnt Signaling Pathway Endosomal Transport Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Wnt Signaling Pathway Embryonic Cleavage Signal Transduction Positive Regulation Of SMAD Protein Import Into Nucleus Protein Localization To Lysosome Stress Fiber Assembly Regulation Of Wnt Signaling Pathway Regulation Of Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Chromosome Segregation Positive Regulation Of Secretion Negative Regulation Of Signal Transduction Regulation Of SMAD Protein Import Into Nucleus Membrane Invagination COPII Vesicle Coating Signaling Negative Regulation Of Signaling Cell Communication Regulation Of Vesicle-mediated Transport Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Targeting To Vacuole	Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Organelle Organization Chromosome Organization Positive Regulation Of Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression DNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Cell Cycle Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process DNA Replication Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cell Division Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Modification Cell Cycle Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition
Tagcloud ?		apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tubules tunica ubiquitous ubiquitously uterus vesicle	augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Difference) ?		apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tubules tunica ubiquitous ubiquitously uterus vesicle	augments becomes cd31 cdkn1a cdkn2a clorgyline combines conjugate degrades dye emt goals hypoxic inactivating infrared m30 maoa micromolar modern moiety monoamine monoamines multidisciplinary neurotransmitters nfkb nmi oncogenes pca pharmacology
Tagcloud (Intersection) ?