RHOBTB3 and BHLHE40

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RHOBTB3	BHLHE40
Gene Name		Rho-related BTB domain containing 3	basic helix-loop-helix family, member e40
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Golgi Apparatus
	Molecular Function	Protein Binding ATP Binding GTP Binding ATPase Activity Rab GTPase Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Small GTPase Mediated Signal Transduction Metabolic Process Retrograde Transport, Endosome To Golgi	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BHLHE40 CCNE1 CUL3 HGS RAB9A RBPMS RBX1 RHOBTB2 UBXN11	49 interactors: AAMP AANAT AES APH1A ARNTL BHLHE41 BRD7 BTRC CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 FBXW11 GMCL1P1 HDAC1 HIVEP1 KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMYD1 SOX15 STAT3 STK19 TOB2 TOLLIP TTC23 TXNL4B VAC14 VIM ZHX1
Entrez ID		22836	8553
HPRD ID		09557	16050
Ensembl ID		ENSG00000164292	ENSG00000134107
Uniprot IDs		O94955	O14503 Q6IB83
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Monoubiquitination Positive Regulation Of Exocytosis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Trophectodermal Cellular Morphogenesis Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Exocytosis G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Transport Negative Regulation Of Wnt Signaling Pathway Endosomal Transport Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Targeting To Lysosome Wnt Signaling Pathway Embryonic Cleavage Signal Transduction Positive Regulation Of SMAD Protein Import Into Nucleus Protein Localization To Lysosome Stress Fiber Assembly Regulation Of Wnt Signaling Pathway Regulation Of Cellular Localization Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Chromosome Segregation Positive Regulation Of Secretion Negative Regulation Of Signal Transduction Regulation Of SMAD Protein Import Into Nucleus Membrane Invagination COPII Vesicle Coating Signaling Negative Regulation Of Signaling Cell Communication Regulation Of Vesicle-mediated Transport Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Targeting To Vacuole	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Rhythmic Process RNA Metabolic Process Regulation Of Circadian Rhythm Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Histone Modification Chromatin Modification Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Protein Metabolic Process Developmental Process Chromosome Organization Regulation Of Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Protein Acetylation Biosynthetic Process
Tagcloud ?		apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tubules tunica ubiquitous ubiquitously uterus vesicle	ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected tubules univariable vegfa weaker wilms wts
Tagcloud (Difference) ?		apparatus atypical cartilage embryo endosomes expresses galactosidase golgi gtpases histochemical investigating lacz localizes northern organism pave persists preliminary seminiferous testicular testis trafficking tunica ubiquitous ubiquitously uterus vesicle	ang angiogenic angiogenin cd31 colocalized fk fks glomeruli helix hypoxia lactate ldha microvascular mrnas mvd mvds nephrogenesis nks paired perinecrotic recapitulates reflected univariable vegfa weaker wilms wts
Tagcloud (Intersection) ?		tubules