RHOBTB3 and BHLHE40

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		RHOBTB3	BHLHE40
Description		Rho related BTB domain containing 3	basic helix-loop-helix family member e40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Trans-Golgi Network Membrane Extracellular Exosome	Chromatin Nucleus Cytoplasm Nuclear Body
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Small GTPase Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Male Gonad Development Regulation Of Proteolysis Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis
Pathways		Retrograde transport at the Trans-Golgi-Network RHOBTB3 ATPase cycle	BMAL1:CLOCK,NPAS2 activates circadian expression Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases
GWAS			Cognitive function in longevity ( 33607172) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Serum alkaline phosphatase levels ( 33547301) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		18 interacting genes: BHLHE40 CCNE1 CUL3 EFHC2 HGS IHO1 L3MBTL3 PLAGL2 RAB9A RBPMS RBX1 RHOBTB2 RIPPLY3 SNCA TBX15 UBXN11 USP54 VHL	91 interacting genes: AAMP AANAT APH1A ATXN1 BHLHE41 BMAL1 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 FXR1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MTCL2 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM11 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOX15 STAT3 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WHR1 WT1 ZFHX3 ZHX1
Entrez ID		22836	8553
HPRD ID		09557	16050
Ensembl ID		ENSG00000164292	ENSG00000134107
Uniprot IDs		O94955	O14503 Q6IB83
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Molecular Adaptor Activity Negative Regulation Of TORC1 Signaling Cul3-RING Ubiquitin Ligase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of RNA Biosynthetic Process Positive Regulation Of Exocytosis Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Autophagy Negative Regulation Of Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Modification-dependent Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Renal Sodium Ion Transport Regulation Of Nucleobase-containing Compound Metabolic Process Homologous Chromosome Pairing At Meiosis Regulation Of Transcription By RNA Polymerase II Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Amyloid Fibril Formation Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress Regulation Of TOR Signaling Proteolysis Involved In Protein Catabolic Process Regulation Of Gene Expression Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nuclear RNA Surveillance Regulation Of Macromolecule Biosynthetic Process Receptor-mediated Endocytosis RNA Surveillance Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Intermediate Filament Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Myoblast Differentiation Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Rhythmic Process Cytoplasmic Stress Granule Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process E-box Binding Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Circadian Rhythm Regulation Of Alternative MRNA Splicing, Via Spliceosome Chromatin Remodeling DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Myoblast Differentiation Regulation Of RNA Splicing Mitogen-activated Protein Kinase Kinase Kinase Binding
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