ATG12 and KRTAP4-12

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATG12	KRTAP4-12
Gene Name		autophagy related 12	keratin associated protein 4-12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Membrane Atg12-Atg5-Atg16 Complex	Keratin Filament
	Molecular Function	Protein Binding Atg8 Ligase Activity	Protein Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Cellular Response To Nitrogen Starvation Negative Regulation Of Type I Interferon Production Nucleophagy Innate Immune Response
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP ATG10 ATG3 ATG5 ATG7 CRX KRTAP4-12 MDFI PLSCR1 PTK2	107 interactors: ADAMTSL4 ALPP AQP1 ATG12 ATN1 BAHD1 BEX2 C10orf62 C19orf66 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CHCHD3 CHIC2 CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 DBF4B DLK2 EIF4E2 FAM107A FAM27E3 FAM76B FBXL18 FBXW5 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 ILF3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP3-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2D LCE3E LCE4A LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NOTCH2NL NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP PRKAB2 PRR13 QPRT RERE RPS28 SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY2 TAP1 TBC1D16 TBC1D23 TCEB3B THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF581 ZNF638 ZNF655 ZNF764 ZSCAN26
Entrez ID		9140	83755
HPRD ID		08496	13941
Ensembl ID		ENSG00000145782	ENSG00000213416
Uniprot IDs		O94817	Q9BQ66
PDB IDs		4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Nucleophagy Negative Regulation Of Histone H4-K16 Acetylation Mitochondrion Degradation Autophagy Organelle Disassembly Negative Regulation Of Histone H4 Acetylation Response To Stress Negative Stranded Viral RNA Replication Positive Regulation Of Cellular Metabolic Process Protein Lipidation Positive Regulation Of Mucus Secretion Regulation Of Histone H4 Acetylation Lipoprotein Biosynthetic Process Regulation Of Mucus Secretion Apoptotic Process Response To External Stimulus Negative Regulation Of Histone Acetylation Programmed Cell Death Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cell Death Negative Regulation Of Peptidyl-lysine Acetylation Death Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Acetylation Positive Regulation Of Cellular Protein Metabolic Process Viral Genome Replication Regulation Of Cilium Assembly Lipoprotein Metabolic Process Response To Starvation Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Platelet Activation C-terminal Protein Lipidation Cellular Response To Extracellular Stimulus Response To Stimulus Cellular Response To Stress Autophagic Vacuole Assembly Regulation Of Histone Acetylation Central Nervous System Neuron Axonogenesis Macroautophagy Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Organ Development Cardiac Muscle Cell Development Mitochondrion Organization Regulation Of Cellular Amino Acid Metabolic Process	Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Keratinization Anterior/posterior Pattern Specification Regulation Of Cellular Process Regulation Of Metabolic Process Cellular Process Keratinocyte Differentiation Embryo Development Phospholipid Scrambling Metanephric Glomerulus Vasculature Development Pattern Specification Process Metanephric Glomerulus Development Epidermal Cell Differentiation Epidermis Development Mitochondrion Organization Metabolic Process Forebrain Morphogenesis Transcription From RNA Polymerase II Promoter Glomerulus Vasculature Development Multicellular Organismal Development Organic Anion Transport Inner Ear Development Cell Migration Involved In Coronary Angiogenesis Hepatic Duct Development Abducens Nerve Formation Metanephric Mesenchymal Cell Migration Transepithelial Water Transport Renin Secretion Into Blood Stream Metanephric Descending Thin Limb Development DGDP Catabolic Process Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development
Tagcloud ?		akt1 antipsychotic atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		akt1 antipsychotic atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?