ATG12 and ATG3

Number of citations of the paper that reports this interaction (PubMedID 11825910)
0

Data Source:
HPRD (in vivo)

		ATG12	ATG3
Description		autophagy related 12	autophagy related 3
Image
GO Annotations	Cellular Component	Autophagosome Membrane Nucleoplasm Cytoplasm Autophagosome Cytosol Membrane Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Transferase Complex	Phagophore Assembly Site Cytoplasm Cytosol Atg12-Atg5-Atg16 Complex
	Molecular Function	Protein Binding Atg8-family Ligase Activity Protein Tag Activity	Protein Binding Transferase Activity Atg8-family Ligase Activity Atg12 Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding Atg8-family Conjugating Enzyme Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Macroautophagy Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Glycophagy Autophagosome Maturation Regulation Of Autophagosome Maturation Positive Regulation Of Viral Translation	Autophagosome Assembly Autophagy Of Mitochondrion Protein Targeting To Membrane Autophagy Protein Transport Macroautophagy Protein Ubiquitination Mitochondrial Fragmentation Involved In Apoptotic Process Nucleophagy Negative Regulation Of Phagocytosis Glycophagy Regulation Of Cilium Assembly
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	Macroautophagy
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)	Asthma (childhood onset) ( 23829686)
Interacting Genes		18 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 NLRP6 PLSCR1 PRKACA PTK2 RB1CC1 SERTAD1 SERTAD2	6 interacting genes: ATG12 ATG7 GABARAP GABARAPL2 MAP1LC3B MOB2
Entrez ID		9140	64422
HPRD ID		08496	10654
Ensembl ID		ENSG00000145782	ENSG00000144848
Uniprot IDs		O94817	Q9NT62
PDB IDs		4GDK 4GDL 4NAW	4NAW 8AFI 8FKM
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Nucleophagy Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Atg12 Transferase Activity Negative Regulation Of Phagocytosis Microautophagy Atg8-family Ligase Activity Regulation Of Phagocytosis Phagophore Assembly Site Positive Regulation Of Metabolic Process Defense Response To Virus Autophagy Regulation Of Endocytosis Atg12-Atg5-Atg16 Complex Mitophagy Regulation Of Mucus Secretion Response To Virus Negative Regulation Of Endocytosis Cellular Response To Nitrogen Starvation Cellular Component Assembly Glycophagy Vascular Endothelial Cell Response To Fluid Shear Stress Cytoplasm Cytosol Response To Lead Ion Ubiquitin-like Protein Transferase Activity Glycogen Catabolic Process Regulation Of Vesicle-mediated Transport Phagophore Assembly Site Membrane Positive Regulation Of Catabolic Process Axoneme Polysaccharide Catabolic Process Molecular Function Activator Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of JNK Cascade Postsynaptic Modulation Of Chemical Synaptic Transmission Cellular Response To Fluid Shear Stress Regulation Of Metabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway	Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagosome Autophagy Phosphatidylethanolamine Binding Protein-containing Complex Disassembly Cellular Response To Starvation Response To Starvation Organelle Assembly Cellular Response To Nutrient Levels Axoneme Phospholipid Binding Response To Nutrient Levels GABA Receptor Binding Piecemeal Microautophagy Of The Nucleus Microautophagy Nucleophagy Microtubule Binding Beta-tubulin Binding Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Cellular Component Assembly Atg8 Activating Enzyme Activity Atg12 Activating Enzyme Activity Organelle Organization Protein-containing Complex Organization Positive Regulation Of Viral Translation Cellular Response To Stress Cytosol Atg8-family Ligase Activity Positive Regulation Of Protein K48-linked Ubiquitination Cellular Response To Hyperoxia Atg12-Atg5-Atg16 Complex Regulation Of Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cytoplasmic Vesicle Positive Regulation Of Protein Catabolic Process Ceramide Binding Endomembrane System Ubiquitin-like Modifier Activating Enzyme Activity Glycophagy Protein Transport
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