ATG12 and CRX

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ATG12	CRX
Gene Name		autophagy related 12	cone-rod homeobox
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Membrane Atg12-Atg5-Atg16 Complex	Nucleus Transcription Factor Complex
	Molecular Function	Protein Binding Atg8 Ligase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Cellular Response To Nitrogen Starvation Negative Regulation Of Type I Interferon Production Nucleophagy Innate Immune Response	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Visual Perception Circadian Rhythm Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Photoreceptor Cell Differentiation Response To Stimulus Retina Development In Camera-type Eye
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP ATG10 ATG3 ATG5 ATG7 CRX KRTAP4-12 MDFI PLSCR1 PTK2	44 interactors: ABI2 AES ATG12 ATXN7 BANF1 C1orf109 C9orf72 CA8 CCNC CREBBP CSNK1G2-AS1 EIF5A EP300 GCM2 GUCD1 IPO13 KAT2A KIAA0141 KLHL32 LARP4 LONRF1 M1AP MDFI MLLT6 NIP7 NPAS2 NR2E3 NRL OSGIN1 PARK2 PDC PID1 PPP1R16B PRKAB2 PSMB10 QRICH1 RAX2 RBFOX1 ROR2 SFI1 SOX5 STK16 SZT2 UBXN2B
Entrez ID		9140	1406
HPRD ID		08496	03748
Ensembl ID		ENSG00000145782	ENSG00000105392
Uniprot IDs		O94817	O43186
PDB IDs		4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Nucleophagy Negative Regulation Of Histone H4-K16 Acetylation Mitochondrion Degradation Autophagy Organelle Disassembly Negative Regulation Of Histone H4 Acetylation Response To Stress Negative Stranded Viral RNA Replication Positive Regulation Of Cellular Metabolic Process Protein Lipidation Positive Regulation Of Mucus Secretion Regulation Of Histone H4 Acetylation Lipoprotein Biosynthetic Process Regulation Of Mucus Secretion Apoptotic Process Response To External Stimulus Negative Regulation Of Histone Acetylation Programmed Cell Death Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cell Death Negative Regulation Of Peptidyl-lysine Acetylation Death Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Acetylation Positive Regulation Of Cellular Protein Metabolic Process Viral Genome Replication Regulation Of Cilium Assembly Lipoprotein Metabolic Process Response To Starvation Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Platelet Activation C-terminal Protein Lipidation Cellular Response To Extracellular Stimulus Response To Stimulus Cellular Response To Stress Autophagic Vacuole Assembly Regulation Of Histone Acetylation Central Nervous System Neuron Axonogenesis Macroautophagy Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Organ Development Cardiac Muscle Cell Development Mitochondrion Organization Regulation Of Cellular Amino Acid Metabolic Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Rhodopsin Gene Expression N-terminal Peptidyl-lysine Acetylation Regulation Of Rhodopsin Gene Expression Transcription, DNA-templated Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitochondrial Fusion Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Autophagy N-terminal Protein Amino Acid Acetylation Nuclear Envelope Reassembly Cellular Response To Stimulus Response To Stimulus Negative Regulation Of Wnt Signaling Pathway Cellular Metabolic Process Somitogenesis Cellular Nitrogen Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone Deubiquitination Neurological System Process Somite Development Cellular Response To Stress Regulation Of Type I Interferon Production Peptidyl-amino Acid Modification Peptidyl-lysine Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		akt1 antipsychotic atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate photoreceptor pigmentation playing progenitor prolongs remarkably repressing retinal retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Difference) ?		akt1 antipsychotic atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	5sa aspect cofactor embryos exit hippo lats1 morphogenesis mst1 mst2 neurogenesis orchestrate otx5 phosphorylate photoreceptor pigmentation playing progenitor prolongs remarkably repressing retinal retinogenesis rhodopsin rx1 tead ww yap zebrafish
Tagcloud (Intersection) ?