ATG12 and DOCK9

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ATG12	DOCK9
Description		autophagy related 12	dedicator of cytokinesis 9
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleoplasm Cytoplasm Autophagosome Cytosol Membrane Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Transferase Complex	Cytosol Endomembrane System Membrane
	Molecular Function	Protein Binding Atg8-family Ligase Activity Protein Tag Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Macroautophagy Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Glycophagy Autophagosome Maturation Regulation Of Autophagosome Maturation Positive Regulation Of Viral Translation	Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)	Appendicular lean mass ( 33097823) Asthma (childhood onset) ( 31036433) Blood urea nitrogen levels ( 29403010 31152163) Corneal astigmatism ( 30306274) FEV1 ( 30804560) Heel bone mineral density ( 28869591 30598549) Lung function (FEV1/FVC) ( 30804560) Myocardial infarction ( 33532862) Nonsyndromic cleft palate ( 31609978) Platelet distribution width ( 32888494) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 NLRP6 PLSCR1 PRKACA PTK2 RB1CC1 SERTAD1 SERTAD2	11 interacting genes: ATG12 CDC42 CLK1 FHL1 LNX1 MYOT NEDD9 NUCKS1 PPP2R5E SNAPIN TAF1
Entrez ID		9140	23348
HPRD ID		08496	09542
Ensembl ID		ENSG00000145782	ENSG00000088387
Uniprot IDs		O94817	A0A0A0MT38 A0A804HIE8 A6H8Z6 B3KXE2 B7Z2G6 B9EG73 Q9BZ29 X6RGR3
PDB IDs		4GDK 4GDL 4NAW	1WG7 2WM9 2WMN 2WMO
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Nucleophagy Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Atg12 Transferase Activity Negative Regulation Of Phagocytosis Microautophagy Atg8-family Ligase Activity Regulation Of Phagocytosis Phagophore Assembly Site Positive Regulation Of Metabolic Process Defense Response To Virus Autophagy Regulation Of Endocytosis Atg12-Atg5-Atg16 Complex Mitophagy Regulation Of Mucus Secretion Response To Virus Negative Regulation Of Endocytosis Cellular Response To Nitrogen Starvation Cellular Component Assembly Glycophagy Vascular Endothelial Cell Response To Fluid Shear Stress Cytoplasm Cytosol Response To Lead Ion Ubiquitin-like Protein Transferase Activity Glycogen Catabolic Process Regulation Of Vesicle-mediated Transport Phagophore Assembly Site Membrane Positive Regulation Of Catabolic Process Axoneme Polysaccharide Catabolic Process Molecular Function Activator Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of JNK Cascade Postsynaptic Modulation Of Chemical Synaptic Transmission Cellular Response To Fluid Shear Stress Regulation Of Metabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway
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