ATG12 and IER2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATG12	IER2
Description		autophagy related 12	immediate early response 2
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Nucleoplasm Cytoplasm Autophagosome Cytosol Membrane Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Transferase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Atg8-family Ligase Activity Protein Tag Activity	DNA Binding Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Macroautophagy Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Glycophagy Autophagosome Maturation Regulation Of Autophagosome Maturation Positive Regulation Of Viral Translation	Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Motility Response To Fibroblast Growth Factor
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)	Age at first birth ( 34211149) Height ( 31562340) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 NLRP6 PLSCR1 PRKACA PTK2 RB1CC1 SERTAD1 SERTAD2	2 interacting genes: ATG12 HSF2BP
Entrez ID		9140	9592
HPRD ID		08496	09997
Ensembl ID		ENSG00000145782	ENSG00000160888
Uniprot IDs		O94817	Q9BTL4
PDB IDs		4GDK 4GDL 4NAW
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Nucleophagy Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Atg12 Transferase Activity Negative Regulation Of Phagocytosis Microautophagy Atg8-family Ligase Activity Regulation Of Phagocytosis Phagophore Assembly Site Positive Regulation Of Metabolic Process Defense Response To Virus Autophagy Regulation Of Endocytosis Atg12-Atg5-Atg16 Complex Mitophagy Regulation Of Mucus Secretion Response To Virus Negative Regulation Of Endocytosis Cellular Response To Nitrogen Starvation Cellular Component Assembly Glycophagy Vascular Endothelial Cell Response To Fluid Shear Stress Cytoplasm Cytosol Response To Lead Ion Ubiquitin-like Protein Transferase Activity Glycogen Catabolic Process Regulation Of Vesicle-mediated Transport Phagophore Assembly Site Membrane Positive Regulation Of Catabolic Process Axoneme Polysaccharide Catabolic Process Molecular Function Activator Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of JNK Cascade Postsynaptic Modulation Of Chemical Synaptic Transmission Cellular Response To Fluid Shear Stress Regulation Of Metabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway	Glycogen Catabolic Process Phagophore Assembly Site Membrane Atg8-family Ligase Activity Atg12-Atg5-Atg16 Complex Positive Regulation Of Viral Translation Regulation Of Autophagosome Maturation Glycophagy Protein Tag Activity Polysaccharide Catabolic Process Microautophagy Negative Regulation Of Defense Response To Virus Nucleophagy Transferase Complex Piecemeal Microautophagy Of The Nucleus Double-strand Break Repair Involved In Meiotic Recombination Female Meiotic Nuclear Division Female Meiosis I Male Meiosis I Meiosis I Negative Regulation Of Type I Interferon Production Autophagosome Maturation Male Meiotic Nuclear Division Autophagosome Membrane Regulation Of Defense Response To Virus Glycogen Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Viral Process Autophagy Of Mitochondrion Polysaccharide Metabolic Process Meiosis I Cell Cycle Process Meiotic Nuclear Division Autophagosome Phagocytic Vesicle Membrane Nuclear Division Autophagosome Assembly Negative Regulation Of Innate Immune Response Autophagosome Organization Carbohydrate Catabolic Process Regulation Of Protein-containing Complex Disassembly Regulation Of Type I Interferon Production Regulation Of Viral Process
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