ATG12

Description		autophagy related 12
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleoplasm Cytoplasm Autophagosome Cytosol Membrane Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Transferase Complex
	Molecular Function	Protein Binding Atg8-family Ligase Activity Protein Tag Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Macroautophagy Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Glycophagy Autophagosome Maturation Regulation Of Autophagosome Maturation Positive Regulation Of Viral Translation
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)
Novel Interacting Genes		1 novel interacting genes: SRP19
Interacting Genes		18 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 NLRP6 PLSCR1 PRKACA PTK2 RB1CC1 SERTAD1 SERTAD2
Entrez ID		9140
HPRD ID		08496
Ensembl ID		ENSG00000145782
Uniprot IDs		O94817
PDB IDs		4GDK 4GDL 4NAW
Enriched GO Terms of Interacting Partners?		Autophagy Of Mitochondrion Nucleophagy Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Atg12 Transferase Activity Negative Regulation Of Phagocytosis Microautophagy Atg8-family Ligase Activity Regulation Of Phagocytosis Phagophore Assembly Site Positive Regulation Of Metabolic Process Defense Response To Virus Autophagy Regulation Of Endocytosis Atg12-Atg5-Atg16 Complex Mitophagy Regulation Of Mucus Secretion Response To Virus Negative Regulation Of Endocytosis Cellular Response To Nitrogen Starvation Cellular Component Assembly Glycophagy Vascular Endothelial Cell Response To Fluid Shear Stress Cytoplasm Cytosol Response To Lead Ion Ubiquitin-like Protein Transferase Activity Glycogen Catabolic Process Regulation Of Vesicle-mediated Transport Phagophore Assembly Site Membrane Positive Regulation Of Catabolic Process Axoneme Polysaccharide Catabolic Process Molecular Function Activator Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of JNK Cascade Postsynaptic Modulation Of Chemical Synaptic Transmission Cellular Response To Fluid Shear Stress Regulation Of Metabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway
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