CLDN1 and MMP2

Number of citations of the paper that reports this interaction (PMID 11382769)
30

Data Source:
HPRD (in vivo)

		CLDN1	MMP2
Gene Name		claudin 1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Tight Junction Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Cell Adhesion Viral Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Establishment Of Skin Barrier	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus
Pathways		Cell junction organization Cell-cell junction organization Tight junction interactions	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix
Drugs			Marimastat Captopril SC-74020
Diseases
GWAS		Working memory ( 21107309)
Protein-Protein Interactions		12 interactors: BRD4 CLDN3 DRG1 INADL LNX1 MMP14 MMP2 MPDZ TJP1 TJP2 TJP3 WNK4	34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		9076	4313
HPRD ID		04760	00386
Ensembl ID		ENSG00000163347	ENSG00000087245
Uniprot IDs		A5JSJ9 O95832	P08253
PDB IDs			1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Establishment Of Endothelial Intestinal Barrier Response To Hypoxia Anatomical Structure Development Establishment Of Endothelial Barrier Hippo Signaling Tissue Development Epithelium Development Response To Abiotic Stimulus Epithelial Cell Development Endodermal Cell Differentiation Regulation Of Cell Cycle Checkpoint Developmental Process Endothelial Cell Development Endoderm Formation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Collagen Catabolic Process Cell-cell Signaling Involved In Cell-cell Junction Organization Execution Phase Of Apoptosis Collagen Metabolic Process Endothelial Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Endothelium Development Extracellular Matrix Disassembly Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Blastocyst Development Cell Development Intracellular Signal Transduction Distal Tubule Morphogenesis Cell-cell Junction Assembly Regulation Of Cell Cycle Process Embryo Development Formation Of Primary Germ Layer Negative Regulation Of DNA Damage Checkpoint Renal Sodium Ion Absorption Response To Magnetism Histone H3-K14 Acetylation Epithelial Cell Differentiation Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Myelination Axon Ensheathment Positive Regulation Of Spindle Checkpoint Cell Differentiation Multicellular Organismal Development Astrocyte Cell Migration Gastrulation Histone H4-K12 Acetylation Intramembranous Ossification	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process
Tagcloud ?		aldh1a1 anxa1 bcar1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Intersection) ?