CLDN1 and MPDZ

Number of citations of the paper that reports this interaction (PubMedID 11689568)
0

Data Source:
HPRD (in vitro, two hybrid)

		CLDN1	MPDZ
Description		claudin 1	multiple PDZ domain crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Protein-containing Complex Tight Junction Anchoring Junction	Cytoplasm Plasma Membrane Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cell Projection Neuron Projection Apical Part Of Cell Synapse Anchoring Junction
	Molecular Function	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Cell Adhesion Establishment Of Blood-nerve Barrier Response To Toxic Substance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Response To Ethanol Symbiont Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Xenobiotic Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate	Tight Junction Assembly
Pathways		Tight junction interactions
Drugs
Diseases		Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS		Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)	Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Corneal hysteresis ( 30894546 32716492) Corneal structure ( 23291589) Heel bone mineral density ( 28869591 30598549) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)
Interacting Genes		18 interacting genes: BRD4 CD69 CD79A CLDN3 DRG1 FNDC9 LNX1 MMP14 MMP2 MPDZ MS4A3 PATJ TJP1 TJP2 TJP3 TMEM179B TMEM9 WNK4	19 interacting genes: ABCA1 CAMK2A CCDC88C CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PELI2 PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2 VANGL2
Entrez ID		9076	8777
HPRD ID		04760	09155
Ensembl ID		ENSG00000163347	ENSG00000107186
Uniprot IDs		A5JSJ9 O95832	O75970
PDB IDs			2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?		Bicellular Tight Junction Tight Junction Positive Regulation Of Blood-brain Barrier Permeability Cell-cell Junction Organization Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Anchoring Junction Endothelial Cell Development Regulation Of Blood-brain Barrier Permeability Cell Junction Organization Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability Protein Localization To Cell-cell Junction Apical Junction Complex Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Vascular Permeability Tight Junction Assembly Membrane Tight Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Protein Localization To Cell Junction Apical Part Of Cell Multicellular Organismal-level Homeostasis Cell Adhesion Molecule Binding Cell Junction Assembly Vascular Process In Circulatory System Cell-cell Junction Maintenance Apicolateral Plasma Membrane Circulatory System Process Plasma Membrane Regulation Of T-helper 17 Cell Differentiation Endodermal Cell Differentiation Regulation Of T-helper 17 Type Immune Response Collagen Catabolic Process Regulation Of Cell Adhesion Regulation Of Cell Fate Commitment Ovarian Follicle Development Extracellular Matrix Disassembly Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Cell Junction Histone H4K8ac Reader Activity Aldosterone Secretion Regulation Of T-helper Cell Differentiation Cell Junction Maintenance Regulation Of Lymphocyte Differentiation Homeostatic Process Transmembrane Signaling Receptor Activity	Regulation Of Biological Quality Plasma Membrane Cell-cell Junction Regulation Of Bicellular Tight Junction Assembly PDZ Domain Binding Regulation Of Cell Communication Regulation Of Signaling Maintenance Of Blood-brain Barrier Tight Junction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Learning Visual Learning Regulation Of Neuronal Synaptic Plasticity Visual Behavior Regulation Of MAPK Cascade Positive Regulation Of Bicellular Tight Junction Assembly Lateral Plasma Membrane Cell Junction Signal Transduction Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Endothelial Intestinal Barrier G Protein-coupled Receptor Signaling Pathway Associative Learning Response To Alcohol Positive Regulation Of Signal Transduction Regulation Of Establishment Of Endothelial Barrier Learning Or Memory Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Response To Ethanol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Ruffle Organization Cognition Bicellular Tight Junction Regulation Of Long-term Neuronal Synaptic Plasticity Phosphatidylinositol-3,4-bisphosphate Binding Face Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress
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