PLAGL1 and PML

Number of citations of the paper that reports this interaction (PMID 20097304)
0

Data Source:
BioGRID (pull down)

		PLAGL1	PML
Gene Name		pleiomorphic adenoma gene-like 1	promyelocytic leukemia
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Early Endosome Membrane Nuclear Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Metal Ion Binding	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding Protein Homodimerization Activity SMAD Binding Protein Heterodimerization Activity Cobalt Ion Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Apoptotic Process Cell Cycle Arrest Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Response To Hypoxia Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Targeting Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Negative Regulation Of Cell Growth PML Body Organization Positive Regulation Of Histone Deacetylation Negative Regulation Of Telomere Maintenance Via Telomerase Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Gene Expression Negative Regulation Of Translation In Response To Oxidative Stress Response To Cytokine Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Cell Fate Commitment Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Retinoic Acid Receptor Signaling Pathway Protein Stabilization Maintenance Of Protein Location In Nucleus Defense Response To Virus Negative Regulation Of Telomerase Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Interferon-gamma-mediated Signaling Pathway Branching Involved In Mammary Gland Duct Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Cellular Senescence Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Height ( 20881960) Myopia (pathological) ( 23049088) Paget's disease ( 21623375)
Protein-Protein Interactions		9 interactors: CREBBP DAXX EP300 KAT2B PIAS2 PML SMAD3 TP53 UBE2I	101 interactors: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 FOS GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NCOA2 NCOR1 NCOR2 NFKB1 NR3C1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PPARG PSMA3 RARA RB1 RBX1 RELA RNF111 RNF125 RNF4 RPL11 RXRA SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SMAD3 SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIM24 TRIM27 TRIM69 UBE2I UBE2U UBE3A ZBTB16 ZFYVE9
Entrez ID		5325	5371
HPRD ID		16010	00023
Ensembl ID		ENSG00000118495	ENSG00000140464
Uniprot IDs		A1YLA1 A1YLA2 Q9UM63	P29590
PDB IDs			1BOR
Enriched GO Terms of Interacting Partners?		Viral Process N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Cell Cycle Process Negative Regulation Of Transcription, DNA-templated Peptidyl-lysine Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Hypoxia Rhythmic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Transcription, DNA-templated Apoptotic Signaling Pathway RNA Biosynthetic Process N-terminal Protein Amino Acid Modification Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Notch Signaling Pathway Cell Cycle Arrest Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Deacetylation Regulation Of Signaling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Gene Expression Mitotic Cell Cycle Process Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Somitogenesis Chromatin Organization Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Somite Development Protein Stabilization	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Gene Expression Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Cell Cycle
Tagcloud ?		20mug 25mug 5mug actionable bisulfite deemed dmrs exposures h19 hek ig igf2 imprinted imprinting meg3 mest methylation nnat pb peg1 peg10 peg3 physiologically pyrosequencing reportable seventy sgce utero vulnerable	anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast
Tagcloud (Difference) ?		20mug 25mug 5mug actionable bisulfite deemed dmrs exposures h19 hek ig igf2 imprinted imprinting meg3 mest methylation nnat pb peg1 peg10 peg3 physiologically pyrosequencing reportable seventy sgce utero vulnerable	anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast
Tagcloud (Intersection) ?