SPAG9 and ARF6

Number of citations of the paper that reports this interaction (PubMedID 35844135)
78

Data Source:
BioGRID (x-ray crystallography, pull down, proximity labelling technology, proximity labelling technology)

		SPAG9	ARF6
Description		sperm associated antigen 9	ARF GTPase 6
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity Identical Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity
	Biological Process	MAPK Cascade Vesicle-mediated Transport Positive Regulation Of Cell Migration Lysosome Localization Retrograde Transport, Endosome To Golgi Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Striated Muscle Cell Differentiation Negative Regulation Of Dendrite Extension	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development
Pathways		Myogenesis Myogenesis	TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling
Drugs			5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Body fat mass ( 28552196) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)	Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)
Interacting Genes		13 interacting genes: ARF6 KLC1 MAP1LC3B MAP2K4 MAP3K3 MAPK14 MAPK8 MAX MYC NFKB1 PNRC2 SNCA TP53BP1	40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709
Entrez ID		9043	382
HPRD ID		10398	02714
Ensembl ID		ENSG00000008294	ENSG00000165527
Uniprot IDs		O60271 Q5JB53	P62330
PDB IDs		2W83	1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD
Enriched GO Terms of Interacting Partners?		MAPK Cascade Response To Mechanical Stimulus Myc-Max Complex Response To Molecule Of Bacterial Origin Cellular Response To Molecule Of Bacterial Origin Cellular Senescence JNK Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intracellular Signaling Cassette Cellular Response To Mechanical Stimulus Apoptotic Process Protein-containing Complex Organization Cell Death Programmed Cell Death Cellular Response To Stress Regulation Of Immune System Process MAP Kinase Activity MAP Kinase Kinase Activity Response To Lipopolysaccharide Response To Growth Factor Protein Serine Kinase Activity Positive Regulation Of Cyclase Activity Intracellular Signal Transduction Regulation Of Presynapse Assembly Cytoplasm Regulation Of Presynapse Organization Response To Muscle Stretch Negative Regulation Of Macromolecule Metabolic Process Stress-activated MAPK Cascade Protein Serine/threonine Kinase Activity Stress-activated Protein Kinase Signaling Cascade Protein-containing Complex Disassembly Fc-epsilon Receptor Signaling Pathway Protein Localization To Site Of Double-strand Break Response To UV Response To Radiation Cellular Response To Radiation Negative Regulation Of Metabolic Process Canonical Inflammasome Complex Assembly Cellular Response To Lipopolysaccharide Negative Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Synaptic Vesicle Endocytosis Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Activity Presynaptic Endocytosis	Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion
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