SPAG9 and KLC1

Number of citations of the paper that reports this interaction (PubMedID 15987681)
0

Data Source:
HPRD (two hybrid, in vivo)

		SPAG9	KLC1
Description		sperm associated antigen 9	kinesin light chain 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cytoplasmic Vesicle Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity Identical Protein Binding	Cytoskeletal Motor Activity Protein Binding Kinesin Binding
	Biological Process	MAPK Cascade Vesicle-mediated Transport Positive Regulation Of Cell Migration Lysosome Localization Retrograde Transport, Endosome To Golgi Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Striated Muscle Cell Differentiation Negative Regulation Of Dendrite Extension	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly
Pathways		Myogenesis Myogenesis	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)
Interacting Genes		13 interacting genes: ARF6 KLC1 MAP1LC3B MAP2K4 MAP3K3 MAPK14 MAPK8 MAX MYC NFKB1 PNRC2 SNCA TP53BP1	29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB
Entrez ID		9043	3831
HPRD ID		10398	02489
Ensembl ID		ENSG00000008294	ENSG00000126214
Uniprot IDs		O60271 Q5JB53	F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2
PDB IDs		2W83	3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		MAPK Cascade Response To Mechanical Stimulus Myc-Max Complex Response To Molecule Of Bacterial Origin Cellular Response To Molecule Of Bacterial Origin Cellular Senescence JNK Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intracellular Signaling Cassette Cellular Response To Mechanical Stimulus Apoptotic Process Protein-containing Complex Organization Cell Death Programmed Cell Death Cellular Response To Stress Regulation Of Immune System Process MAP Kinase Activity MAP Kinase Kinase Activity Response To Lipopolysaccharide Response To Growth Factor Protein Serine Kinase Activity Positive Regulation Of Cyclase Activity Intracellular Signal Transduction Regulation Of Presynapse Assembly Cytoplasm Regulation Of Presynapse Organization Response To Muscle Stretch Negative Regulation Of Macromolecule Metabolic Process Stress-activated MAPK Cascade Protein Serine/threonine Kinase Activity Stress-activated Protein Kinase Signaling Cascade Protein-containing Complex Disassembly Fc-epsilon Receptor Signaling Pathway Protein Localization To Site Of Double-strand Break Response To UV Response To Radiation Cellular Response To Radiation Negative Regulation Of Metabolic Process Canonical Inflammasome Complex Assembly Cellular Response To Lipopolysaccharide Negative Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Synaptic Vesicle Endocytosis Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Activity Presynaptic Endocytosis	Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade
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