IFT20 and DISC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		IFT20	DISC1
Gene Name		intraflagellar transport 20	disrupted in schizophrenia 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Golgi Apparatus Centrosome Centriole Cilium Microtubule Cytoskeleton Intraciliary Transport Particle B Motile Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Dendrite Terminus Extracellular Vesicular Exosome Primary Cilium Ciliary Tip Ciliary Base	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane
	Molecular Function	Opsin Binding Protein Binding	Protein Binding
	Biological Process	Kidney Development Organelle Organization Smoothened Signaling Pathway Visual Learning Protein Localization To Golgi Apparatus Photoreceptor Cell Outer Segment Organization Opsin Transport Intraciliary Transport Cilium Assembly Centrosome Localization Cardiac Muscle Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Neural Precursor Cell Proliferation Protein Localization To Cilium Regulation Of Cilium Assembly Regulation Of Autophagic Vacuole Assembly	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Organelle biogenesis and maintenance Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS			Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		29 interactors: ABI2 BLOC1S6 CCDC53 CCDC67 CROCCP2 DISC1 DTNBP1 EMILIN1 EXOC7 FBF1 FSD2 GOLGA2 HAUS1 HTT IFT57 KIF3B KPNA2 KRT13 KXD1 MED4 NDC80 NUP54 NUP62 PSMA1 PTPN12 TREX1 USHBP1 WASF1 ZDHHC17	113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		90410	27185
HPRD ID		17137	05553
Ensembl ID		ENSG00000109083	ENSG00000162946
Uniprot IDs		Q8IY31	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Microtubule-based Process Cytoskeleton Organization Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Anterograde Axon Cargo Transport Mitotic Cell Cycle Process Microtubule Cytoskeleton Organization Microtubule-based Movement Establishment Of Organelle Localization Cellular Localization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Organization Establishment Of Localization In Cell Positive Regulation Of Actin Nucleation Establishment Of Vesicle Localization Cell Cycle Vesicle Localization Organelle Localization Cell Cycle Process Organelle Assembly Protein Localization Movement Of Cell Or Subcellular Component Centrosome Organization Intracellular Transport Nucleocytoplasmic Transport Anterograde Synaptic Vesicle Transport Nuclear Transport Rac Protein Signal Transduction Microtubule Organizing Center Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Establishment Of Cell Polarity Melanosome Organization Pigment Granule Organization Regulation Of Actin Nucleation Spindle Organization Protein Transport Vesicle Transport Along Microtubule Mitotic Nuclear Envelope Disassembly Establishment Of Protein Localization Cytoplasmic Transport Establishment Of Mitotic Spindle Orientation Nuclear Envelope Disassembly Establishment Or Maintenance Of Cell Polarity Mitotic Spindle Organization Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Neural Plate Formation	Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization
Tagcloud ?		anchors apparatus assembled caenorhabditis centrosomal chlamydomonas cilia cilium displaces dyf elipsa flag gmap210 golgi hspb11 ift172 ift25 ift54 ift54s ift88 immunoprecipitate intraflagellar liss localize motil orthologue orthologues traf3ip1	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Difference) ?		anchors apparatus assembled caenorhabditis centrosomal chlamydomonas cilia cilium displaces dyf elipsa flag gmap210 golgi hspb11 ift172 ift25 ift54 ift54s ift88 immunoprecipitate intraflagellar liss localize motil orthologue orthologues traf3ip1	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Intersection) ?