UBE2D2 and UBR4

Number of citations: 0 (PubMedID 29643511)
Data Source: BioGRID (pull down)

		UBE2D2	UBR4
Name		ubiquitin conjugating enzyme E2 D2	ubiquitin protein ligase E3 component n-recognin 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Protein Autoubiquitination Protein K48-linked Ubiquitination	Cytoplasmic Translation Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Fatty Acid Biosynthetic Process Response To Oxidative Stress Endosome Organization Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Negative Regulation Of Fatty Acid Biosynthetic Process Protein Stabilization Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control HRI-mediated Signaling Negative Regulation Of HRI-mediated Signaling Protein Branched Polyubiquitination
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		(R,R)-2,3-Butanediol	Verpasep caltespen Picolinic acid
GWAS		Alzheimer's disease (late onset) ( 30820047 ) Body mass index ( 26426971 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Leukocyte telomere length ( 32109421 )	Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Composite immunoglobulin trait (IgA/IgG) ( 28628107 )
Interacting Genes		244 interacting genes: AMFR ANAPC11 ANAPC2 AREL1 ARIH2 ARRDC3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRAP BRCA1 BTRC CADPS2 CBL CBLB CBLC CCNB1 CDKN1B CHFR CNOT4 COP1 CUEDC1 CUL3 DCAF1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 HACE1 HECTD1 HECTD3 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC4 HUWE1 ITCH KAT2B KCMF1 LNX1 LNX2 LRSAM1 LTN1 MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF6 MARCHF7 MDM2 MDM4 MEX3A MEX3C MGRN1 MIB1 MIB2 MID1 MID2 MKRN2 MKRN3 MUL1 MYCBP2 MYLIP NAT10 NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NPR1 NSMCE1 OBI1 OTUB1 PDZRN3 PELI1 PHF7 PHRF1 PJA1 PJA2 PMAIP1 POLL POLM PRKN QSOX1 RAD18 RAF1 RAG1 RBCK1 RBX1 RC3H1 RC3H2 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF144A RNF146 RNF149 RNF150 RNF151 RNF166 RNF167 RNF168 RNF170 RNF181 RNF185 RNF186 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF224 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF40 RNF43 RNF5 RNF7 RNF8 RSPRY1 RTF2 SIAH1 SIAH2 SMURF1 SMURF2 SNCA SOCS6 SPOP STAM2 STK11 STUB1 SYVN1 TOPORS TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM11 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM34 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM46 TRIM47 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM65 TRIM7 TRIM8 TRIP12 TTC3 UBA1 UBA3 UBA5 UBA6 UBASH3B UBD UBE3A UBE3C UBE4A UBE4B UBOX5 UBR1 UBR2 UBR3 UBR4 UBR5 UFM1 UHRF1 UHRF2 UVSSA VHL VPS11 VPS18 WSB1 WWP1 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	18 interacting genes: ACE2 ADRA1A AGTR1 CALM1 ERG HSPA13 MTNR1A MTNR1B MYCN PRPF40A SRGN SRPK2 SUMO2 TTC3 UBC UBE2B UBE2D2 UBE2L3
Entrez ID		7322	23352
HPRD ID		04268	10184
Ensembl ID		ENSG00000131508	ENSG00000127481
Uniprot IDs		P62837	Q5T4S7
PDB IDs		1UR6 1W4U 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG 4DDI 4LDT 4V3K 4V3L 4WZ3 5D0K 5D0M 5D1K 5D1L 5D1M 5EDV 5MNJ 5ULF 5ULH 5ULK 5VZW 5ZBU 6HPR 6M2C 6SQO 6SQR 6SQS 6TTU 6W7Z 6W9D 7AI0 7AI1 7BOL 7R71 8B3I 8GBQ 8GCB 8GRM 8JWJ 8JWU 8V0D 8VK8 8VK9	8B5W 8BTL 8J9Q 8J9R
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Zinc Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Metal Ion Binding Catabolic Process Protein Autoubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Protein Monoubiquitination Response To Stress Regulation Of Signal Transduction Immune System Process Cellular Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Protein Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Ubiquitin Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction Defense Response To Symbiont	Regulation Of Vasoconstriction Regulation Of Blood Circulation Melatonin Receptor Activity Ubiquitin Conjugating Enzyme Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Action Potential Positive Regulation Of Cardiac Muscle Contraction Protein Modification By Small Protein Conjugation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Nucleoplasm Positive Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction Protein Modification Process Proteolysis Protein Tag Activity Ubiquitin-protein Transferase Activity Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of System Process Protein Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Circulatory System Process Protein Ubiquitination Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Reactive Oxygen Species Metabolic Process Presynaptic Cytosol G Protein-coupled Receptor Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Muscle Contraction Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Protein K11-linked Ubiquitination G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Angiotensin Type I Receptor Activity Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Regulation Of Heart Contraction Positive Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine